Find Research Studies | CHOP Research Institute

Find Research Studies | CHOP Research Institute

1 - 347 of 347

16BT052; Unrelated And Partially Matched Related Donor PSCT w/ TCR αβ depletion for patients with BMF

18F-DOPA PET/CT scan for Hyperinsulinism

22CT015: CART 19-22 co-administration

22LL011; Epcoritamab in B-cell Neoplasms

A

A Study to Evaluate the Safety and Efficacy of a Single Dose of CTX001 in Subjects With Severe Sickle Cell Disease

AA Genetic Study

AALL1131; A Phase 3 Randomized Trial for HR B-ALL with Dasatinib Arm in Ph-like TKI Sensitive Mutations

AALL1521; Ruxolitinib and Chemotherapy for Patients with JAK-Mutant B-ALL

AALL2121: SNDX-5613 for Relapsed or Refractory Leukemia

AAML1921; Bosutinib for Chronic Myeloid Leukemia

ABA3 GVHD ProRx post Allo HACT

Abatacept Registry

Abemaciclib For Solid Tumors

ADHD ETA Driving Cohort Study

ADHD ETA Naturalistic Driving Study

Adolescent Communication of Emotion Study (ACES)

Afamitresgene Autoleucel in Pediatric Subjects with MAGE-A4 Positive Tumors

Allergic Inflammation Study

Allo CD7 CAR WU-CART-007

Alpelisib in PIK3CA Associated Lymphatic Malformations

Alpelisib in PIK3CA-related overgrowth syndrome

ALRN-6924 in Pediatric Cancer

Alterra Adaptive Clinical Trial

Aneurysms in ARPKD

Approach Avoidance Model of Repetitive Behaviors

Arimoclomol Early Access Program for Niemann-Pick Disease

ARPKD/HRFD Database

Assent and Decision-Making Study in Down Syndrome

Assessing Optically Pumped Magnetoencephalography (MEG)

Astellas Clinical Trial for ASP0367

Autism ETA Cohort Study

Autism Quality of Life

B

BA3011 for advanced solid tumors

Beta-cell Responsiveness to the Incretin Hormones (Aim1)

Blood Sugar Stability in Individuals with Hyperinsulinism

BMT CTN 1503 (STRIDE2): BMT for SCD

Body Surface Gastric Mapping in Patients with GI Symptoms

Bone Marrow Failure Research Study and Repository

BPD STAR Pilot Trial

Brain and Behavior Learning Health System Biorepository

Brain Chemistry of Infants with HIV Exposure

Brains Keep Changing

Breath Biomarkers of Mitochondrial Dysfunction

BUFFET-Snack: Food Selectivity Study for Autistic Youth

C

Cabo/Ifos in EWS and Osteo

CAMEO: Pediatric Crohn's Disease Outcomes Study

Camouflaging in Autism and Other Conditions

Canagliflozin in Children with Type 2 Diabetes

Cancer Genomic Testing Study

Car Seat Injury & Prevention Center Study

Carfilzomib in ALL

CATC Biorepository

CFRD-Pilot Study

Chemotherapy-induced Nausea and Vomiting Control

Childhood Type 2 Diabetes Study of a Single Dose of "LY3209590" a Weekly Insulin Injection

Children's Brain Tumor Network Collection Protocol

CHOP-ALS20 Lentiviral gene Therapy for Beta Thalassemia

Chronic Incretin-based therapy in Cystic Fibrosis (Aim 2)

Coaching and Asynchronous Remote Training for Evidence-Based Practices (CARE)

Collaborative Registry for Williams Syndrome

Comorbidity of Autism and Epilepsy

Contrast-Enhanced Ultrasound Evaluation of Bowel Perfusion in Necrotizing Enterocolitis

Contrast-Enhanced Ultrasound Evaluation of Hypoxic Ischemic Injury

Copanlisib in Solid Tumors or Lymphoma

CP-SMC Pilot Study

Craniofacial Pathologies

CrCEST MRI in Mitochondrial Disease

CTX and Idiopathic Bilateral Cataracts in Pediatric Patients

D

Dasiglucagon for the Treatment of Children with Congenital Hyperinsulinism

Dasiglucagon for the Treatment of Children with Congenital Hyperinsulinism (for children under 1 year of age)

DCA Trial in PDC Deficiency

DECLINE-2 Determining Caregivers' Logic In Saying No to Research

Defining Clinically Meaningful Outcome Measures For Children With Axial Juvenile Spondyloarthritis

Designate - Siplizumab in T1DM

Designing the ThyTSQ for Teens and Parents

DECLINE- Determining Caregivers' Logic In Saying No to Research

Distracted Driving App Study

Dova Study for Children with Immune Thrombocytopenia (ITP)

Down Syndrome and Sleep Apnea Study (DOSA)

Drive Focus Study

Driving After Concussion in Adolescents

DTX401 Gene Therapy in Glycogen Storage Disease (GSD) Type Ia

E

Early Driving among Adolescents with CHD

EDIT-301: Phase 1/2 Sickle Cell Disease Gene Therapy Trial

EIT During Invasive Mechanical Ventilation Pilot

Elamipretide for Adult Patients with Primary Mitochondrial Disease

Emergence and Progression of AGT

Endotheliopathy in Oncology

Environmental Influences on Child Health Outcomes (ECHO)

Eosinophilic Esophagitis (EoE)-Causal Food Assay

Ertugliflozin for Children and Adolescents with Type 2 Diabetes

Evaluation of Diffuse Amplified Musculoskeletal Pain Syndrome Using MEG

Executive Function and Healthcare Transition in IMD

Executive Functioning in Adolescents with Eating Disorders

Exercise in Craniopharyngioma

F

Facial Nerve Paralysis Database

FLG Mutations and Atopic Dermatitis

Flo Prospective Trials

Floreo Focus Groups

Fludarabine/Cytarabine/Gemtuzumab Ozogamicin With or Without Venetoclax in Relapsed AML

Fontan Liver MRE

Food Allergy Anxiety

Food Genetics Behavior Study (FOODIE)

FrexalimAB in preservation of endogenous insULIN secretion compared to placebo in adUlts and adolescents on top of inSulin therapy (FABULINUS)

Friedreich Ataxia Clinical Outcomes Measures

FVRx + Home Plate

G

Gastrointestinal Motility Biorepository

GD2CART for Osteosarcoma or Neuroblastoma

Gene Therapy Trial for Hemophilia A

Genomics of Nephrotic Syndrome

Gladiolus Study

Gluten-Free Diet Adherence in Children with Celiac Disease

GM1 Gangliosidosis Gene Therapy Study

Gut Health (Microbiome) in Adolescents with Anorexia Nervosa

H

Head Start 4 Protocol for Children with Medulloblastoma and CNS Embryronal Tumors

Health Behavior Adolescent CHD

Health Disparities in Pediatric Sleep

Healthy Brain and Child Development Study

Healthy Children Needed for Single Study Visit on Immunometabolic Dysregulation

Healthy Controls EndoPAT

HGB-212: Phase 3 Beta Thalassemia LentiGlobin BB305 Gene Therapy Trial

HM15136 for the Treatment of Congenital Hyperinsulinism Research Study

Hodgkin Lymphoma (NHL) (BIANCA)

HR-pQCT Pilot Study

HRpQCT in Childhood Osteoporosis

Humanized CART19 Phase 2 Trial

Hunter Syndrome JR-141 Study

Hypnotherapy in Functional Abdominal Pain Disorders

I

ILAR Reclassification Study

Imaging Assessment of Bone Sarcomas

Imaging Cognition and Neurodevelopment (ICAN)

Infant-Caregiver Synchrony in Autism

Inflammatory Bowel Disease and Yoga

Institutional Biobank

Intranasal Oxytocin in Hypothalamic Obesity

J

Juvenile SpA Repository

K

L

Larotrectinib RAI Thyroid

Larsen Syndrome: Risk factors for Thoracic Insufficiency Syndrome

Leftover Surgical Specimen Collection Study (Brain Tumor Focus)

Leigh Syndrome Natural History Study

LEOPARDS Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

LeukoSEQ: First-Line Whole Genome Sequencing in Leukodystrophies

Lifespan Brain Institute Common Screening and Intake Protocol

Literacy Focus Group

Locomotor Learning- Infant MEG

Lurbinectedin in Ewing Sarcoma

Lutathera in Somatostatin Neuroendocrine Tumors

Lysosomal Storage Disease Registry

M

Managing Feeding and Sleep at Home

MAS825 Trial for NLRC4-GOF

MECCI: Molecular Epidemiology of Childhood Critical Illness

Medtronic 780G System

MEG Biomarkers in Autistic Adults

Melatonin, Sleep, and Mental Health

Metabolic MRI: Pilot Testing

Microbiome, Antibiotics and Growth Infant Cohort (MAGIC) Study

Mitochondrial Myopathy Rating Scale

ML-004 for Adolescents and Adults With ASD

Moderna mRNA Clinical Trial for Patients with GSD 1a

MPS Biomarkers of Joint Disease

MRI Assessment of NAD+

MRI Muscle Metabolism in Different Age Groups

MRI of ARPKD liver disease

MRI Study for Infants with Down Syndrome

MRI Study for Prediction of ASD

mRNA-3705 MMA Study

MSeqDR Data Collection and Sharing

Multimodal Imaging in Autism

Myofascial release therapy in IBS

N

National Pediatric Cardiology Quality Improvement Collaborative

Natural History of Homocystinuria

Natural History of PMM2-Congenital Disorder of Glycosylation

NEPENTHE - Next Generation Personalized Neuroblastoma Therapy

Neurocognition in Hyperinsulinism

Neurofibromatosis 1 Optic Glioma's - Understanding the mechanisms of Vision Loss for Visual Restoration Strategies

Neurometabolic Profile of Tobacco Smoking in HIV-Infected Individuals

Neurophysiological Biomarkers in Rett Syndrome

Neuroscience Center Biorepository

NICU RISE (Rotavirus Immunization Safety Evaluation)

Non-Invasively Assessing Lung Ventilation in Pediatrics

Novel Imaging Techniques in Autosomal Recessive Polycystic Kidney Disease

O

Omics Study For CDG Patient

Online Mindfulness Course for Pediatric IBD

Optimizing Vancomycin Therapy in Children

Oral Desensitization

OT-58 for Homocystinuria

OTOF Hearing Loss Gene Therapy

P

Palbociclib, Irinotecan, and Temozolomide in Ewing Sarcoma

PANDA Study – Mobile App

Parenting Intervention Study

Partnering to Achieve School Success (PASS) Study

Pathways to ASD Diagnosis

PBS for Renal Tumors

Pediatric KIDney Stone (PKIDS) Care Improvement Network

Pediatric Mito MRI Study

Pediatric Neurodegenerative Biorepository

Pediatric Normative Data for the Complete Minnesota Dexterity Test

Pediatric Research Immune Network on SARS-CoV-2 and MIS-C (PRISM)

Pediatric Study of Acute Recurrent and Chronic Pancreatitis

PEDSnet Research Prioritization Strategy

PERCEPTION Study

Phase 1 Study Of Lentivirally Transduced T Cells Engineered To Contain Anti-CD123 In Subjects With Refractory Or Relapsed Acute Myeloid Leukemia

Phase 1 Trial of CUDC-907

Phase 2 trial of CART19 for Orphan Indications Of Pediatric B Cell Acute Lymphoblastic Leukemia (B-ALL)

Phase 3 Beta Thalassemia LentiGlobin BB305 Gene Therapy Trial

Phase II Mayo Clinic Stem Cell Trial for HLHS

Phenotypes of Congenital Hyperinsulinism

Phenotyping Congenital Hyperinsulinism

Pimavanserin for the Treatment of Irritability Associated With ASD

Polyethylene Glycol Safety in Children

Posterity Trial

Preventing Distracted Driving

Prevention of Urinary Stones with Hydration

PriCARE for Young Parents Yr1

PRISM and CFN for PMD

Prodigy huCART19

Progression of SMA

Project RISE (Resources and Internal Supports for Evidence-based Practices)

PRONTO-PEDS: Ultra-Rapid Insulin Lispro in T1D

Providing Unique Support for Health (PUSH)

PTEN Hamartoma Tumor Syndrome Phenotyping

R

Regeneron for Hemophilia B

Registry of Patients with Lysosomal Acid Lipase Deficiency

REN001 for Adults with Primary Mitochondrial Myopathy

Repotrectinib for ALK, ROS1, or NTRK1-3 Alterations

Research Study for Individuals with Hyperinsulinism, Type 1 Diabetes Mellitus, and Healthy Children

Research Study for Individuals with Hyperinsulinism/Hyperammonemia

RGX-111 Gene Therapy in Patients With Mucopolysaccharidosis Type I (MPS I)

RGX-121 Gene Therapy in Patients With MPS II (Hunter Syndrome)

Ribociclib With Everolimus And Dexamethasone For Relapsed ALL

RIZE Clinical Trial for Individuals with Hyperinsulinism

RM-493-034: Setmelanotide in MC4R Study

RM-493-035: Setmelanotide in Patients with Gene Defects in the MC4R Pathway

S

Safety and Efficacy of Early-Start Deferiprone Treatment in Infants and Young Children Newly Diagnosed with Transfusion-Dependent Beta Thalassemia

Safety and Efficacy of NB-001 in 22q11DS Children with Anxiety, Inattention, and/or Autism

Sangamo Gene Therapy for Thalassemia (ST-400-01)

SAR443579 in AML, B-ALL, or MDS

SECURE-AIC Registry

Seeking Healthy Participants for Muscle Accrual Study

Selpercatinib in Solid or CNS tumors with RET-Alterations

Selpercatinib in Thyroid Cancer (Collaboration with the International Thyroid Oncology Group)

Selpercatinib RAI Thyroid (RAISE Trial)

Sex, Gender, and Camouflage in ASD

Shifting Perspectives

Skeletal and Dental Quality in Adolescents with Urinary Stone Disease

Skeletal Growth Study

Sleep and Growth Study 2

Sleep Apnea in People with Beckwith-Wiedemann Syndrome

Sleep Questionnaire for Infants with or at high-risk of Cerebral Palsy

Sleep Study for Children With Down Syndrome - In Lab and At Home

SOAR Studying Outcomes of Autistic Individuals Transitioning to Adulthood

Social Coordination

Social Processes in Adolescent Anorexia Nervosa

Somatosensory Evoked Potentials at Different Positions in children with cerebral palsy

SPARK: Simons Foundation Powering Autism Research for Knowledge

Stem Cell Transplant for Sickle Cell Disease or Thalassemia Major

Structural Development of Human Infant Brain

Study of Breathing During Sleep in Infants with Micrognathia and Healthy Infants

Study of Efficacy and Safety of Tisagenlecleucel in Children and Young Adults with HR B-ALL that is end-consolidation MRD Positive (AALL1721/CASSIOPEIA)

Study of Rifampin as a Treatment for Elevated Calcium Levels in Patients with Genetic Vitamin D Excess

Study on Brain Responses During Simulated Driving

Studying the Clinical Course of Risankizumab

SECURE-VA Registry

Synovial Sarcoma Registry / Biospecimen Repository

T

T2017-002 TACL Ixazomib Study

TACL-2020-003; IDEAL2 Study

Tara-002 in Lymphatic Malformations

TAS-117 in Tumors Harboring Germline PTEN Inactivating Mutations

Tegavivint for the Treatment of Solid Tumors, Lymphomas & Desmoids

Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy

Teplizumab in New-Onset Type 1 Diabetes

The Bladder Brain Connection - Why Are Some Children Wet?

The CARRA Registry

The Charisma Study

The FARE Patient Registry

The LiFFT Study

The LIGHTHOUSE Study: A Gene Therapy Clinical Trial for X-Linked Retinoschisis

The Myelin Disorders Biorepository Project (MDBP)

The SLEEPY Study

ThecaFlex Investigational Device for the Treatment of SMA

Therapeutic Role Playing Games for Autistic Individuals

Therapeutic use of Tadekinig alfa in NLRC4 mutation and XIAP deficiency

Thyroidectomies

Tiragolumab and Atezolizumab in SMARCB1 or SMARCA4 Deficient Tumors

Topical Sirolimus for Microcystic Lymphatic Malformations

TransPrEP Phase 3: 3T Intervention

Trial of Erenumab for Preventive Treatment of Pediatric migraine 15 days per month or more

Trial of Erenumab in Children and Teens with Migraine less than 15 days per month

U

Upadacitinib Trial for Polyarticular JIA

Uproleselan in Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) or Mixed Phenotype Acute Leukemia (MPAL)

V

Vactosertib in Osteosarcoma

Visual Measures in Pediatric MS

Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia (HI/HA) Syndrome

Vocal Biomarkers of Autism Spectrum Disorder

VR Intervention to Improve Police Safety

W

Walking and Talking in Autism

Weight Trajectory with ETI

What Do You Eat? An Online Study for Youth with ASD