Accelerating Breakthroughs

Explore our research.

Inside the Research Institute

For almost a century, Children’s Hospital of Philadelphia Research Institute has advanced breakthrough treatments and innovations that have changed lives and pushed pediatric scientific knowledge forward. It’s truly amazing what an elite scientific research institution can accomplish with an engaged professional community, the shared resources on a premier academic campus, and the commitment to excellence at a world-renowned children’s hospital. From laboratory discoveries, to new public policies, to health gains, we want to give every child the best opportunity for a bright future.

Cornerstone Blog
Using structure-guided design, we’ve developed a new way to design better antibiotics. Given the growing concern over antimicrobial resistance, we think this is an important step forward.

– Audrey Odom John, MD, PhD
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Cornerstone Blog
Tunable Switch Via Oral Small Molecule Controls Gene Therapy Expression Levels Oral Small Molecule Helps to Fine-Tune Gene Therapy Expression
Oral Small Molecule Helps to Fine-Tune Gene Therapy Expression
Children’s Hospital of Philadelphia scientists developed a tunable switch system to control levels of gene therapy expression.
Featured Service
Participate in Research
Participate in Research
By participating in a clinical research study, you can create healthier futures for children by advancing our understanding of diseases and treatment, and improving health, safety, and wellness across the lifespan.

Annual Report
2020 Research Annual Report

2020 Research Annual Report

The Research Institute’s 2020 Annual Report highlights achievements across our scientific strategic pillars: rare and complex diseases, lifespan research, novel therapeutics, precision medicine, and more.