Emergence and Progression of AGT



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The purpose of this research study is to test how people with cystic fibrosis process sugar and learn more about their risk of developing cystic fibrosis-related diabetes. We will also test the body's ability to make insulin in response to sugar. 

Who Do I Contact?

If you are interested in participating in the study or want to learn more please contact our study team at steelem1 [at] chop.edu or 267-425-1033.

Eligibility & Criteria

IRB #:
Official Title:
Emergence and Progression of Abnormal Glucose Tolerance in Cystic Fibrosis (Aim 1)
Study Phase:
Not Applicable
Eligible Age Range:
6 - 99 Years
Study Categories:

Visit Criteria

This study requires 3 visits to the Main Hospital at CHOP. These visits will be repeated over the span of 5 years. Study participants will be screened to confirm eligibility. A DXA scan measures body composition and will be completed. You will also be asked to complete an Oral Glucose Tolerance Test (OGTT), a Mixed Meal Tolerance Test (MMTT), and a Glucose Potentiated Arginine test (GPA). A series of blood draws will be conducted during each procedure. An OGTT will require consumption of glucola, a sugary drink. The OGTT test measures how the body reacts to sugar and its susceptibility to diabetes. The MMTT will require coordination with a dietician for a meal as this procedure is looking at your body's response to food. The GPA requires infusion of sugar as well as a naturally occurring amino acid. This tests the body's ability to make insulin in response to sugar. All procedures require overnight fasting.