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Phenotyping Congenital Hyperinsulinism
This study is now recruiting.
The Congenital Hyperinsulinism Center at the Children's Hospital of Philadelphia is working on a research study to better understand how people with hyperinsulinism may have different blood sugar responses to certain tests (like fasting or drinking a high-protein shake) when compared to people without hyperinsulinism. This study will involve a screening visit where we will ask you about your medical history and any known episodes of low blood sugar. Depending on your responses during the interview, you will be asked to complete up to five tests at our outpatient research center. These tests include fasting, drinking a high-protein shake, drinking a high-sugar drink, eating a regular meal, and exercising on a stationary bike. We will collect blood samples from an IV throughout the tests to measure certain blood levels like glucose and insulin. You will be compensated for some or all of your travel costs and you will receive payment for your time. If you are interested in learning more, please contact us at HIResearch@chop.edu.
If you agree to take part, your participation will last for up to 6 days and will involve up to 6 study visits. First, you will have a 1-hour screening visit where we will confirm you are a good candidate for the study and we will ask you about your medical history to determine which of the following tests you are eligible for. Depending on your answers, we will then ask you complete some or all of the following phenotyping tests at our outpatient research facility:
- Blood draws
- Maximum 24-hour fasting test
- Oral protein tolerance test
- Oral glucose tolerance test
- Mixed meal tolerance test
- Physical exercise test