MRI Assessment of NAD+

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NAD+ (nicotinamide adenine dinucleotide) is an important substance found in the body that plays a role in energy metabolism and overall health. The purpose of this research study is to test the performance of a new magnetic resonance imaging (MRI) technique (spectroscopy) to measure NAD+ metabolism in brain and skeletal muscle. MRI provides pictures of the inside of the body and information about chemicals the body makes.

We are seeking to enroll males and females with Friedrich's Ataxia (FA) as well as healthy matched volunteers, 18 years of age and above. Pregnant females excluded for safety purposes.

Who Do I Contact?

If you are interested in participating in the study or want to learn more please contact our study team at wadekl [at] chop.edu or 267-398-5761.

Eligibility & Criteria

IRB #:
23-020866
Official Title:
Magnetic Resonance Imaging (MRI) Assessment of NAD+ Metabolism in Friedreich’s Ataxia (FA)
Study Phase:
Not Applicable
Eligible Age Range:
18 - 99 Years
Gender:
All
Study Categories:

Visit Criteria

Individuals will complete a Telephone Screening. Eligible participants will be asked to attend a minimum of 1 in-person study visit including:

  • Fasting Labs
  • Questionnaires about Fatigue and Physical Activity (15 - 30 Minutes)
  • MRI (Up to 90 Minutes)

A sub-set of participants will be invited to return for additional study visit(s) to complete MRI scans with different sequences (brain NAD+, calf NAD+).

Leader
Shana E. McCormack

Shana E. McCormack, MD, MTR