Divisions | CHOP Research Institute


Research teams within divisions of the seven academic departments at Children's Hospital of Philadelphia are committed to conducting basic science and clinical research and applying their findings to improve evaluation, diagnosis, treatment, and care of children with challenging and complex pediatric diseases. The divisions' location within a pediatric hospital environment and physician scientists' access to valuable resources at an elite pediatric research institution create unique opportunities for collaboration and innovation.

Generating knowledge on the physical and mental health and well being of adolescents through clinical, translational, population- and community-based research.

Reinforcing and advancing a strong legacy in translational research that focuses on conditions related to aberrant immune function.

Investigating molecular and cellular mechanisms underlying initiation, evolution, and treatment responses of pediatric cancers.

Advancing cardiology care and research through a dynamic and preeminent research program that embraces both clinical and basic science approaches.

Defining the cell biological basis of disease through the use of advanced microscopes to image live cells and tissues.

Illuminating the mechanisms of disease, improving clinical care, and enhancing outcomes for children with developmental and behavioral disorders.

Improving the health and well-being of children by addressing diagnosis and treatment of acutely ill and injured children as well as important social, biological, and environmental determinants of health for children across the continuum of emergency care.

Leading the way in understanding the delicate balance between the genetic, epigenetic, and environmental impacts on the development of endocrine disease.

Conducting research related to the use of different image modalities in utero to evaluate a variety of fetal conditions.

Embracing a research-based approach to prevent, diagnose, and treat digestive, liver, and nutritional diseases to give children the best opportunity for optimal health.

Leading cutting-edge research aimed at the highest value improvements in child health in the world.

Propelling the discovery of novel therapeutics for pediatric hematological disorders with an eye toward improved care for patients.

Identifying and understanding the genetic basis of pediatric disease, discovering the natural history of genetic diseases, and developing novel therapeutic approaches.

Using state-of-the-art data sources, techniques and tools, the research programs within the Division of Infectious Diseases seek to define the mechanisms and outcomes of a wide array of infectious microbes and disease processes.

Providing state-of-the-art interventional radiology research aimed at safety and quality, percutaneous oncologic therapies, MR-guided intervention, and 3D-printed device technology.

Understanding the biology of preterm birth, testing therapeutics through clinical trials, and developing new knowledge about risk factors for poor outcomes in sick neonates.

Contributing breakthroughs in understanding the causes and consequences of kidney disease in children, and working toward developing cures for these rare and complex diseases.

Child Neurology at CHOP is home to world-class integrated clinical, translational, and basic neuroscience research focused on neurological conditions in children and adolescents.

Developing and conducting research to evaluate imaging of the central nervous system in pediatric population.

Leading a robust research program that involves collaborating on a multi-institutional brain tumor tissue consortium and conducting cutting-edge clinical research on pediatric head injuries.

Advancing state-of-the-art cancer investigation and care for children through a world-renowned, integrated basic, translational, and clinical research environment.

Pioneering and advancing research methods for pediatric eye diseases, including retinal degeneration, retinopathy of prematurity, pediatric glaumcoma, and neuro-ophthalmology.

Identifying and characterizing the cellular and molecular mechanisms regulating skeletal development, growth, and morphogenesis and developing new cell- or gene-based tools to treat and correct pediatric skeletal disorders.

Taking a multidisciplinary approach to research in areas like airway and voice disorders, pain management, lithium battery ingestion, hearing loss, and optimal patient outcomes.

Guiding laboratory research through experience treating patients in the clinical setting in order to identify areas of need.

Leveraging innovative experimental methodology, computational approaches, and molecular tools to better understand immune system development, immune response to microorganisms, and mucosal immunology.

Advancing pulmonary research that reflects the child-adult continuum and the trajectory of respiratory diseases and conditions.

Expanding the boundaries of knowledge to enhance the care of children with disabilities.

Delving into the basic, fundamental science that informs the causes and mechanisms of disease in order to develop the next generation of clinical tools.

Investigating the molecular mechanisms affecting function of immune cells in the context of their interactions with foreign antigens.

Growing the connection between laboratory science and clinical research to investigate and treat voiding function and dysfunction in children.