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Division of Transplant Immunology
The Transplant Immunology Division investigates molecular mechanisms affecting function of immune cells in the context of their interactions with foreign antigens, including allogeneic transplants. Current projects in the Division focus on co-stimulatory molecules (such as PD-1 and its ligands PD-L1 and PD-L2) and on chemokines and chemokine receptors in allograft rejection versus tolerance.
Investigators in the Division, which is under the Experimental Pathology Branch of the Department of Pathology and Laboratory Medicine, also research cell cycle regulators and cytokine response elements playing T cell-intrinsic roles in acquired immune tolerance. Planned studies will deepen investigators’ understanding of how metabolic pathway choice affects lymphocyte differentiation into specific effector subsets, and how the immune system is affected by the altered metabolic landscape of the tumor microenvironment in which the nutrient/metabolite pools and environmental conditions (such as hypoxia and acidosis) have been dramatically altered by the metabolic state of the tumor