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Division of Cancer Pathobiology
Investigators in the Division of Cancer Pathobiology use biochemical, molecular genetics, and cell biology approaches to characterize structural and functional abnormalities that define cancerous tumors, while at the same time make them vulnerable to targeted therapies.
Core projects in the Division, which is part of the Department of Pathology and Laboratory Medicine, address the following topics: alternative mRNA splicing as a mechanism of sensitivity and resistance to immunotherapy; broad roles of mRNA splicing and mRNA editing in cancer initiation and progression; identification of alternative targets for cell cycle inhibitor-resistant tumors and cell cycle-unrelated functions of the E2F family of transcription factors; the role of DNA-editing enzymes in genome instability and response to viral oncoproteins; mechanisms of immunoglobulin gene rearrangements; and oncogenic chromosomal translocations.