Mitochondria and Cancer Connections (MC²) Research Program



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The Mitochondria and Cancer Connections (MC2) Research Program launched in 2021 to leverage the combined knowledge of the Mitochondrial Medicine Frontier Program and the Center for Data-Driven Discovery in Biomedicine (D3b). Blending clinical research expertise and advanced bioinformatics infrastructure with diverse cellular and disease model translational research capabilities, the program aims to reveal the precise biological mechanisms and strategies at play at the edge of cellular life and death in two complex pediatric diseases: osteosarcoma and primary mitochondrial disease.

Learning from the growth, survival, strengths, and weaknesses of one disease class versus the other, the MC2 research team and collaborators will shed light on innovative precision treatment strategies for both diseases.

Learn more

Cornerstone Blog
The Center for Precision Medicine for High-risk Pediatric Cancer Frontier Program builds upon ongoing precision medicine efforts across CHOP departments to define and expand treatment options.
Cornerstone Blog
Learn about a technique to analyze large datasets, preclinical results that show safety and efficacy of a drug that could help children with high-risk neuroblastoma, and a milestone in the CORSICA project that seeks to cure rare sinonasal cancers.
Cornerstone Blog
A U.S. Department of Defense grant will support CHOP researchers in their study of noninvasive methods to diagnose mitochondrial diseases.