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Dr. Resnick's research focuses on the cell signaling mechanisms of oncogenesis and tumor progression in brain tumors. He studies signaling cascades and alterations to elucidate the molecular and genetic underpinnings in order to develop targeted therapies. As co-director of the Center of Data-Driven Discovery in Biomedicine, he leads a multidisciplinary team building and supporting a scalable, patient-focused healthcare and educational discovery ecosystem.
Trained as a neuroscientist, Dr. Resnick joined the Department of Neurosurgery in 2007 and began developing a laboratory-based research program dedicated to pediatric brain tumors and the context of their developmental biology. Beginning with an early focus on the characterization of the genetic underpinnings of pediatric low grade gliomas, Dr. Resnick and his research partners engaged efforts to define novel, molecularly informed, targeted approaches for therapeutic intervention in childhood brain cancers.
To support better integration in platforms that would more rapidly inform the preclinical and biochemical modeling of rare diseases, Dr. Resnick and his team launched and participated in new consortia-based approaches for biospecimen-driven research and clinical trials, with the aim of developing scalable ecosystems of collaborative, iterative discovery. These initiatives include the Children's Brain Tumor Tissue Consortium (CBTTC) and the Pacific Pediatric Neuro-Oncology Consortium (PNOC), where Dr. Resnick serves as Scientific Chair. Including more than 20 pediatric hospitals, the consortia provide for the development of research platforms that fully embrace data-driven approaches for brain tumors across ages, diseases, and institutions.
In 2016, Dr. Resnick launched the Center for Data-Driven Discovery in Biomedicine (D³b) at CHOP with co-director Dr. Jay Storm, Chief of the Division of Neurosurgery at CHOP. The Center's activities build on the group's experiences in neuro-oncology and focus on collaborative, data-driven science to harness information-systems-based advancements in technology. Comprised of a diverse set of a multidisciplinary team members, D³b's transformative mission is to build and support a scalable, patient-partnered healthcare discovery and educational ecosystem on behalf of all children.
Education and Training
BS, University of Florida (Neuroscience), 1998
BA, University of Florida (English and Literature), 1999
PhD, Johns Hopkins School of Medicine (Neuroscience), 2006
Titles and Academic Titles
Director, Center for Data-Driven Discovery in Biomedicine (D3b)
Director, Neurosurgical Translational Research, Division of Neurosurgery
Scientific Chair, Children's Brain Tumor Tissue Consortium (CBTTC)
Scientific Chair, Pediatric Neuro-Oncology Consortium (PNOC)
Alexander B. Wheeler Endowed Chair in Neurosurgical Research
Foerderer Award for Excellence, 2008
Howard Temin Pathway to Independence Award in Cancer Research, 2008