Resnick and Storm Laboratory

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Research in the Resnick and Storm Laboratory is dedicated to pediatric brain tumors and the context of their developmental biology. Beginning with an early focus on the characterization of the genetic underpinnings of pediatric low-grade gliomas, the lab team and research partners engaged efforts to define novel, molecularly-informed, targeted approaches for therapeutic intervention in childhood brain cancers.

To support better integration in platforms that would more rapidly inform the preclinical and biochemical modeling of rare diseases, the Resnick and Storm Lab launched and participated in new consortia-based approaches for biospecimen-driven research and clinical trials, with the aim of developing scalable ecosystems of collaborative, iterative discovery. These initiatives include the Children’s Brain Tumor Tissue Consortium (CBTTC) and the Pacific Pediatric Neuro-Oncology Consortium (PNOC). Including more than 20 pediatric hospitals, the consortia provide for the development of research platforms that fully embrace data-driven approaches for brain tumors across ages, diseases, and institutions.

In 2016, the Resnick and Storm Lab launched the Center for Data Driven Discovery in Biomedicine (D³b) at CHOP with Adam Resnick, PhD, research scientist in the Department of Biomedical and Health Informatics, and Phillip "Jay" Storm, MD, Chief of the Division of Neurosurgery, as its co-directors. The Center’s activities build on the group’s experiences in neuro-oncology and focus on collaborative, data-driven science to harness information-systems-based advancements in technology. Comprised of a diverse set of a multidisciplinary team members, D³b's transformative mission is to build and support a scalable, patient-partnered healthcare discovery and educational ecosystem on behalf of all children.

Project Highlights

  • Data Phase – Big Data: Focus on brain tumors in pediatric and adolescent/young adult populations, surgical oncology cross-disease research and comparative biology, and pediatric surgical biospecimen cross-disease research.
  • Information Phase – Harmonization, Transformation and Models: Research focusing on data analysis and preclinical models, with an eye toward bridging the cap to clinical translation.
  • Knowledge Phase – Hypothesis-Driven Research: Research includes biospecimen scientific projects, data scientific programs, and other research and analysis endeavors.