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edwardsj6 [at]
Location - People View

3401 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Jonathan J. Edwards, MD
Jonathan J. Edwards
Attending Physician, Division of Cardiology

Dr. Edwards' focus is on unraveling mechanisms of right ventricular heart failure. To this end, he employs multi-omics approaches to human-derived biospecimens for target discovery and in vitro cardiomyocyte and in vivo mouse models for mechanistic validation and investigation.



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Education and Training

MD, Wake Forest School of Medicine of Wake Forest Baptist Medical Center

Residency, Icahn School of Medicine at Mount Sinai (Pediatrics- Physician Scientist Research Residency)

Fellowship, Children's Hospital of Philadelphia (Pediatric Cardiology)

Fellowship, Children's Hospital of Philadelphia (Pediatric Heart Failure and Transplantation)

Titles and Academic Titles

Attending Physician, Division of Cardiology

Professional Memberships

American Heart Association, 2011-

American College of Cardiology, 2016-

International Society for Heart Lung Transplantation, 2018-

Professional Awards

Gerhard W. Kalmus Scholarship, East Carolina University, 2007

ACS Undergraduate Analytical Chemistry Award, East Carolina University, 2007

Dr. Keith and Susan Holmes Scholastic Award, East Carolina University, 2007

Summa Cum Laude, East Carolina University, 2008

Robert H. Wright Alumni Leadership Award, East Carolina University, 2008

Student Research Program, American Pediatrics Society/Society for Pediatrics Research, 2009

Sarnoff Cardiovascular Research Foundation, Research Fellow, 2011

House Office Research Award, Society for Pediatric Research, 2016

Kurt Hirschhorn Clinician-Scientist Award, Icahn School of Medicine at Mount Sinai, 2016

Publication Highlights

Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z. Comprehensive quantification of fuel use by the failing and non-failing human heart. Science. 2020 Oct; 370(6514): 364-368. PubMed PMID: 33060364
Edwards JJ, Brandimarto J, Hu DQ, Jeong S, Yucel N, Li L, Bedi KC Jr, Wada S, Murashige D, Hwang HTV, Zhao M, Margulies KB, Bernstien D, Reddy S, Arany Z. Noncanonical WNT activation in human right ventricular heart failure. Front Cardiovasc Med. 2020 Oct; 7: 582407. PubMed PMID: 33134326
Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma'ayan A, Gelb BD. Systems analysis implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic Transl Sci. 2020 Apr; 5(4): 376-386. PubMed PMID: 32368696
Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun; 46(6): 635-639. PubMed PMID: 24777450