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Find information and resources about the Research Institute's COVID-19 response
Find information and resources about the Research Institute's COVID-19 response
Hematopoietic stem cells give rise to all circulating blood cells throughout life. Complex signaling pathways lie at the heart of regulating the maintenance of stem cell self-renewal, proliferation, and differentiation. Leukemia often arises in cases of aberrant regulation of signaling transduction, ubiquitination, and DNA damage repair. Genome integrity therefore plays a critical role in the prevention of leukemia, but in aging and blood development as well.
The Tong lab focuses on studying the mechanisms that safeguard the genome during DNA replication and proper control of cytokine signaling transduction to maintain stem cell fitness. In addition, the lab investigates how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia.
Investigator
Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.