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Gene Expression

Faculty Spotlight: Exploring Epigenetic Inheritance via Small RNAs With Colin Conine, PhD

Published on
Jul 27, 2023
in Cornerstone Blog
Colin Conine, PhD
In this Faculty Spotlight, Colin Conine, PhD, shares how receiving the Junior Faculty Award allows him to study how the microbiome and T cells regulate transgenerational epigenetic inheritance.

Sullivan Laboratory

Sullivan Lab

The Sullivan Lab has a broad interest in immune dysfunction. This can underlie susceptibility to infections and autoimmunity and inflammation. The investigators in the lab use cutting-edge approaches to investigate cause in individual patients and to look at population-wide causes of disease.

Can a New Computational Method Help to Prioritize Noncoding Mutations that Disrupt Gene Expression in Pediatric Cancer?

Published on
Aug 3, 2020
in Cornerstone Blog
Snapshot Science: New Computational Method for Noncoding Mutations
Snapshot Science sums up a new computational method to identify noncoding mutations in pediatric cancer.

Does In Utero BPA Exposure Affect Genes Related to Development of Diabetes and Obesity in Amniocytes?

Published on
Feb 21, 2020
in Cornerstone Blog
BPA in Pregnancy
Exposure to BPA in utero during critical periods of fetal development linked to obesity and diabetes.
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Craig H. Bassing, PhD
Craig H. Bassing

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:
bassing [at] chop.edu
Kathleen E. Sullivan, MD, PhD
Photo of Kathleen E. Sullivan

Dr. Sullivan's research focuses on new and rare immunodeficiencies. She has a long-standing interest in one of the most common of the primary immunodeficiencies – chromosome 22q11.2 deletion syndrome. She also investigates common variable immunodeficiency, as well as the genetics and epigenetics of systemic lupus erythematosus.

E-mail:
sullivank [at] chop.edu