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Yi Xing, PhD
Executive Director of the Department of Biomedical and Health Informatics; Director of the Center for Computational and Genomic Medicine
Dr. Xing is the Executive Director of the Department of Biomedical and Health Informatics, the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.
Bio
Dr. Xing’s research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology. He is the the Executive Director of the Department of Biomedical and Health Informatics, the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. Prior to his appointment at CHOP and Penn, Dr. Xing was a professor of Microbiology, Immunology, and Molecular Genetics at University of California Los Angeles, and served as program director of UCLA’s Bioinformatics Interdepartmental PhD Program. Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.
Education and Training
PhD, University of California Los Angeles, (Molecular Biology, Bioinformatics), 2006
Titles and Academic Titles
Executive Director of the Department of Biomedical and Health Informatics
Director of the Center for Computational and Genomic Medicine
Francis West Lewis Endowed Chair in Computational and Genomic Medicine
Professor of Pathology and Laboratory Medicine at the University of Pennsylvania
Publication Highlights
PubMed:
Xin R, Gao Y, Gao Y, Wang R, Kadash-Edmondson KE, Liu B, Wang Y, Lin L, Xing Y. isoCirc catalogs full-length circular RNA isoforms in human transcriptomes. Nat Commun. 2021 Jan; 12(1):266. doi: 10.1038/s41467-020-20459-8. PMID: 33436621; PMCID: PMC7803736
Demirdjian L, Xu Y, Bahrami-Samani E, Pan Y, Stein S, Xie Z, Park E, Wu YN, Xing Y. Detecting Allele-Specific Alternative Splicing From Population-Scale RNA-Seq Data. Am J Hum Genet. 2020 Sep; 107(3): 461-472. PubMed PMID 32781045
Zhang Y, Yang HT, Kadash-Edmondson K, Pan Y, Pan Z, Davidson BL, Xing Y. Regional Variation of Splicing QTLs in Human Brain. Am J Hum Genet. 2020 Aug; 107(2): 196-210. PubMed PMID 32589925
Phillips JW*, Pan Y*, Tsai BL, Xie Z, Demirdjian L, Xiao W, Yang HT, Zhang Y, Lin CH, Cheng D, Hu Q, Liu S, Black DL, Witte ON+, Xing Y+. Pathway-guided analysis identifies Myc-dependent alternative pre-mRNA splicing in aggressive prostate cancers. Proc Nat Acad Sci USA. 2020 Mar; 117(10): 5269-5279. PubMed PMID: 32086391. (+Joint corresponding authors; *Joint first authors)
Zhang Z, Pan Z, Ying Y, Xie Z, Adhikari S, Phillips J, Carstens RP, Black DL, Wu Y, Xing Y. Deep-learning augmented RNA-seq analysis of transcript splicing. Nat Methods. 2019 Apr; 16(4): 307-310. PubMed PMID 30923373