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Yi Xing, PhD
Yi Xing
Director of the Center for Computational and Genomic Medicine

Dr. Xing is the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.

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Bio

Dr. Xing’s research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology. He is the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at Children’s Hospital of Philadelphia, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. Prior to his appointment at CHOP and Penn, Dr. Xing was a professor of Microbiology, Immunology, and Molecular Genetics at University of California Los Angeles, and served as program director of UCLA’s Bioinformatics Interdepartmental PhD Program. Dr. Xing has an extensive publication record in bioinformatics, genomics, and RNA biology. His current research merges the fields of computational biology, biomedical data science, RNA genomics, human genetics, precision medicine, and immuno-oncology.

Education and Training

PhD, University of California Los Angeles, (Molecular Biology, Bioinformatics), 2006

Titles and Academic Titles

Director of the Center for Computational and Genomic Medicine

Francis West Lewis Endowed Chair in Computational and Genomic Medicine

Professor of Pathology and Laboratory Medicine at the University of Pennsylvania

Publication Highlights

Pubmed:
Zhang Z, Pan Z, Ying Y, Xie Z, Adhikari S, Phillips J, Carstens RP, Black DL, Wu Y, Xing Y. Deep-learning augmented RNA-seq analysis of transcript splicing. Nat Methods. 2019 Apr; 16(4): 307-310. PubMed PMID: 30923373
Bahrami-Samani E, Xing Y. Discovery of allele-specific protein-RNA interactions in human transcriptomes. Am J Hum Genet. 2019 Mar; 104(3): 492-502. PubMed PMID: 30827501
Park E, Pan Z, Zhang Z, Lin L, Xing Y. The expanding landscape of alternative splicing variation in human populations. Am J Hum Genet. 2018 Jan; 102(1): 11-26. PubMed PMID: 29304370
Molinie B, Wang J, Lim KS, Hillebrand R, Lu ZX, Wittenberghe NV, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y*, Giallourakis CC*. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome. Nat Methods. 2016 Aug; 13(8): 692-698. PubMed PMID: 27376769 *Joint corresponding authors
Shen S, Park JW, Lu ZX, Lin L, Henry MD, Wu YN, Zhou Q, Xing Y. rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. Proc Natl Acad Sci USA. 2014 Dec; 111(51): E5593-E5601. PubMed PMID: 27279334