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srinivasanl [at] chop.edu
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3401 Civic Center Blvd
Philadelphia, PA 19104
United States

Research Topics
Lakshmi Srinivasan, MD, FAAP
Lakshmi Srinivasan
Attending Neonatologist

Dr. Srinivasan is an attending neonatologist with the Pediatric Sepsis Program and the Division of Neonatology at Children's Hospital of Philadelphia. Her research focuses on biomarkers in neonatal inflammation and infection; and improving prediction, recognition and management of neonatal infections.

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Bio

Dr. Srinivasan is an attending physician in the Division of Neonatology and the Pediatric Sepsis Program at Children’s Hospital of Philadelphia, and the Neonatal Intensive Care Units (NICUs) at Children’s Hospital of Philadelphia and the Hospital of University of Pennsylvania. Her specific areas of interest include improving sepsis recognition and response in the NICU and discovery of biomarker signatures for neonatal sepsis.

Dr. Srinivasan is the hospital-wide CHOP physician leader for prevention of central line-associated bloodstream infections. She also heads the CHOP NICU sepsis quality improvement workgroup, and has successfully led improvement work standardizing the response to sepsis and timely antibiotic administration in the NICU. She is currently guiding the development of a sepsis pathway to improve recognition and management of late-onset sepsis in the CHOP NICU.

Dr. Srinivasan co-leads the NICU sepsis registry project (an ongoing automated repository of clinical data surrounding sepsis evaluations in the NICU) and is a co-investigator on the project to develop an early warning system utilizing the NICU sepsis registry.

Her translational research investigations of biomarkers have included testing of broad range 16s rRNA bacterial PCR for diagnosis of neonatal infections, and development of diagnostic signatures using cytokines and damage-associated molecular patterns. She has performed a pilot gene expression profiling study to better understand genetic risk and expression in neonatal sepsis. She was the lead investigator of the first genome-wide-association study of neonatal sepsis, performed through the NICHD Neonatal Research Network.

Dr. Srinivasan's current research involves the investigation of integrated “omics” approaches for identification of diagnostic and prognostic tools in neonatal diseases. To this end, she is validating pilot data on transcriptomic profiles in neonatal sepsis, and embarking on a concurrent investigation of the metabolome in neonatal sepsis.

Education and Training

MBBS, Madras Medical College, Chennai, India, 2003

MTR, University Of Pennsylvania (Translational Research), 2015

Titles and Academic Titles

Attending Neonatologist

Assistant Professor of Pediatrics