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The Grohar lab strives to develop effective targeted therapies for pediatric solid tumors. We believe in an integrated bench-to-bedside-and-back approach that utilizes mechanistic pharmacology as a bridge between discovery science and the clinic. Our lab utilizes unbiased screens to identify novel targeted agents and drug combinations. We then focus on the mechanism of target suppression to identify novel combination therapies and translate the observations to the in vivo setting. Finally, we design clinical trials with pharmacokinetic/pharmacodynamic biomarkers of target suppression and correlative biology that further informs our preclinical studies.