Dr. Nissim is a biochemist and a pioneer in the application of stable isotopes, mass spectrometry, and nuclear magnetic resonance to study metabolome and fluxome and their coupling to genome in normal and disease states. His long-standing interest focuses on understanding the cause, mechanisms, and outcome of metabolic disorders.

Throughout his career, exemplar projects by Dr. Nissim include: the mechanisms of hepatic metabolic dysfunction and understanding the molecular and metabolome/fluxome malfunction in metabolic syndrome; pathogenic mitochondrial integrity and function; and the molecular and metabolomic characteristics of carcinoma.

During his tenure as director of the Metabolomic Core at Children’s Hospital of Philadelphia, Dr. Nissim collaborated, supported, and contributed to many projects dealing with metabolomics and fluxomics functions in normal and disease states. His research approach incorporates the metabolome and fluxome to the genome by employing techniques such as stable isotopes, liquid chromatography-mass spectrometry, nuclear magnetic resonance, and molecular biology, which has fundamentally transformed the study of major disease processes like cancer, fatty liver disease, metabolic syndrome, and the coupling between neurological function and metabolism.

BSc, Bar Ilan University (Biochemistry), 1972

MSc, Hebrew University (Life Science), 1974

PhD, Weizmann Institute (Biochemistry and Biophysics), 1979

Investigator

Professor of Pediatrics

Professor of Biochemistry and Biophysics

American Society of Nephrology, 1985-

International Society of Nephrology, 1988-

American Chemical Society, 1990-

New York Academy of Sciences, 1995

American Society for Biochemistry and Molecular Biology, 1997-

American Physiologic Society, 1998-

International Union Against Cancer on International Cancer Research Technology Transfer Award, 1979

Research Achievement Award, Children's Hospital of Philadelphia, 1991

Established Investigator Award, American Heart Association, 1991

Research Recognition Award, The Leukemia & Lymphoma Society, Pennsylvania Chapter, 2002