Wolfson Family Laboratory for Clinical and Biomedical Optics



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Through multi-disciplinary collaborations Daniel Licht and his colleagues in the June and Steve Wolfson Family Laboratory for Clinical and Biomedical Optics have used advanced MR techniques and novel optical monitoring devices to probe the neurologic states that exist amongst survivors of complex conditions, including rare congenitial cardiac conditions, ECMO, cardiac arrest, and stroke.

The lab’s goal is to understand the interplay between cerebral hemodynamics and critical clinical pediatric conditions and interventions. Specifically, its research is focused on the development, validation, and translation of various optical and MRI tools with the ultimate goal of clinical therapeutic implementation.

Project Highlights

  • Congenitial Heart Defects: MRI, Diffuse Optical Spectroscopy (DOS), and Diffuse Correlelation Spectroscopy (DCS) measures in a congential heart defect population at CHOP. To date the lab has enrolled more than 180 subjects in this study.
  • Animal Study Models: DOS and DCS validation studies in animal populations undergoing both cardiopulmonary bypass and cardiac arrest. To date, we have conducted studies on more than 100 animals. 
  • ECMO: To assess the cerebral hemodynamic states of patients on ECMO to better understand the effects that ECMO has on cerebral autoregulation. 
  • Pediatric Stroke: To assess the effects that hospital bed angle has on cerebral hemodynamics in a pediatric stroke patient cohort. 
  • Sleep Apnea: To assess cerebral blood flow and cerebral oxygenation in a pediatric sleep apnea patient cohort. 
  • Hydrocephalus: A non-invasive optical instrument validation study to assess intracranial pressure in a population of pediatric hydrocephalus.

Daniel J. Licht, MD

Director, Neurovascular Imaging Lab
Dr. Licht is the director of the Wolfson Family Laboratory for Clinical and Biomedical Optics. His research focuses on the development and use of novel noninvasive optical devices to probe cerebrovascular hemodynamics and physiology in vivo. These devices are used in clinical and preclinical studies to discover the timing and causes of brain injury during care.