Wells Laboratory

The Wells Laboratory studies the cell-intrinsic mechanisms that the immune system uses to decode extracellular signals and translate these into the appropriate immune vs. tolerant responses. The lab has defined a series of intracellular proteins that sense signals from costimulatory and growth factor receptors and translate them into transcriptional responses.

In particular, the Wells Lab studies how transcription factors establish immunoregulatory gene expression programs in T cells through cooperation with chromatin remodeling and DNA methylation complexes. The lab team has two decades of experience in cellular immunology, cell biology, and molecular biology research, including mouse models, in vivo and in vitro human and mouse lymphocyte function, biochemistry, transcriptional biology and epigenetics.

As part of its research, the lab has incorporated approaches such as ChIP-seq, ATAC-seq, 4C-seq and Capture-C to study genome-wide transcription factor occupancy, histone modification, and long-range interactions between enhancers and promoters. These approaches take advantage of deep sequencing resources and the bioinformatic expertise needed to analyze the genome-scale data sets at The Center for Spatial and Functional Genomics, which lab director Andrew Wells, PhD co-directs.