Urological and Renal Disease Engaging Adolescents in Adherence Collaborative Trial



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The Urological and Renal disease Engaging Adolescents in Adherence Collaborative Trial (U-REAACT) is a randomized controlled trial designed to improve treatment adherence for adolescents and young adults (AYA) with kidney transplants and those with spina bifida, who must interrupt their daily lives frequently to take medicines or self-catheterize. This study aims to test an innovative strategy to help them improve their treatment adherence, using mobile phone-based technologies with text reminders, tailored feedback, education, and financial incentives. This research is highly relevant to public health as it targets improving health outcomes through engaging AYA with smartphones and could, if proven effective, be easily catered to other chronic disease populations

Research Project Highlights: 

  • Validating Injury to the Renal Transplant Using Urinary Signatures in Children (VIRTUUS):  The overarching objective of this observational study is to investigate whether existing urinary mRNA and metabolite profiles, which are diagnostic and prognostic for early renal allograft injury in adults, can be validated in pediatric kidney transplant recipients. Additionally, we will create and maintain a DNA database abstracted from saliva, blood, and tissue samples collected throughout the study. This database will be used for ancillary studies.