Terry Laboratory

The epithelial lining of the intestine allows for absorption of nutrients, electrolytes, and fluid while preventing unwanted microbes from entering the body. One cellular subtype within the epithelium, the enteroendocrine population, secretes hormones that direct digestion and absorption. Several disorders which disrupt the enteroendocrine lineage cause a congenital diarrheal disorder. Further, one of the secreted hormones, GLP-2, is a known treatment for short bowel syndrome. Using animal models, the Terry Lab investigates how the enteroendocrine lineage is specified by different transcription factors. These studies will provide a better understanding of why disruption of the enteroendocrine system causes diarrhea, identifying novel ways to treat the diarrheal illness.

Further, thanks to the generosity of patients and their families, the Terry Lab collaborates with the Ghanem Lab to maintain an Enteroid Biorepository. Enteroids are three-dimensional ‘mini-guts’ grown in culture from the epithelial cells of a single biopsy. Thus, with patient-derived tissue in culture, nutrient absorption and electrolyte secretion characteristics can be determined in a variety of disease states. For patients with congenital diarrheal disorders or short bowel syndrome, these enteroids will provide an excellent model system for future drug screening.