Genome-wide Association Studies | CHOP Research Institute
 

Genome-wide Association Studies

Goldmuntz Laboratory

Goldmuntz Lab

The Goldmuntz Laboratory manages a cardiac biorepository of case and parental samples, all of which have congenital heart disease.

Felix Laboratory

Felix Lab

The Felix Lab aims to understand the pathobiology of leukemias with KMT2A (MLL) translocations in order to discover better treatments and preventative approaches.

Could Genomic Biomarkers Help Reduce Incidence of Heart Disease?

Published on
Nov 19, 2019
in Cornerstone Blog
Genomic Biomarkers and Heart Disease
Using eMERGE Network data, researchers identified genome-wide significant loci that might be biomarkers for risk of cardiovascular disease.
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Carolyn A. Felix, MD
Carolyn A. Felix

Dr. Felix uses molecular, biochemical, cellular and in vivo methods to investigate the pathobiology of leukemias with KMT2A (MLL) translocations. Leukemias with these translocations affect infants and young children or occur as a complication of type II topoisomerase (TOP2) poison chemotherapies used for anti-cancer treatment. She aims to develop better treatment and prevention approaches for these leukemias, which have a poor prognosis.

E-mail:
felix [at] chop.edu

Gene Study Points to Novel Pathway for Diabetes Treatment

Published on
Jun 23, 2014
in Cornerstone Blog
New research from The Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania details how a diabetes-related gene functions on a biological pathway that affects the release of insulin.

Autism Gene Networks Could Offer Treatment Targets

Published on
Jun 11, 2014
in Cornerstone Blog
After analyzing the DNA from thousands of patients, investigators from Children’s Hospital have uncovered several gene networks that may play important roles in autism.