This is an open-label, Phase 3 clinical trial evaluating the efficacy of Tofacitinib based on remission in children with moderate to severe ulcerative colitis.
CAPTURE Inflammatory Bowel Disease (IBD) is a multi-center, longitudinal study designed with the goal of advancing precision medicine in pediatric IBD.
Dr. Mattei is an attending physician in the Division of General, Thoracic and Fetal Surgery and specializes in pediatric surgical oncology, inflammatory bowel disease, and minimally invasive and robotic surgery. His research interests are in oncology and IBD.
The purpose of this research study is to help us understand how well tofacitinib works as a treatment for ulcerative colitis or indeterminate colitis in pediatric patients.
Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.
Microbes are on us and in us, and researchers are increasingly becoming aware that they are a vital part of us. Across The Children's Hospital of Philadelphia and University of Pennsylvania a variety of research efforts are underway to understand these populations of bacteria, viruses, and other tiny life forms, known as the microbiome, and their impact on health.
