CTL019 | CHOP Research Institute


Shifting the paradigm to treat the toughest pediatric cancers with new cell therapies that reprogram a patient's own immune system to kill cancer cells.

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

grupp [at] chop.edu
Published on
Dec 14, 2018
In this week’s research roundup: personalized gene therapies reach key milestones and scientists probe CAR T-cell resistance.
Published on
Aug 31, 2017
It was a pivotal moment that has turned into a new era for cancer immunotherapy. On April 17, 2012, Children's Hospital of Philadelphia researchers for the first time treated a pediatric patient with a cellular therapy that used her own reprogrammed immune cells, called T cells, to attack her aggressive form of blood cancer.
Published on
Jul 13, 2017
CAR T-cell therapy tops this week's research roundup, with news about the experimental immunotherapy designed to re-engineer a patient's cells to fight cancer making late-breaking and captivating headlines across the nation.
Published on
May 19, 2017
Our latest research news roundup carries a hint of summer and exciting new beginnings: As more than 70 Children's Hospital of Philadelphia experts traveled to sunny California for the annual Pediatric Academic Societies (PAS) Meeting, back at home, sports medicine research ramped up with new investigations into how we can protect kid's health on (and off) the field.
Published on
Dec 30, 2016
The end of the year has come up fast, and so have important advances in pediatric research at Children's Hospital of Philadelphia. This week's In the News starts off with a celebration of two remarkable patients and their dedicated pediatric oncologist.
Published on
Dec 16, 2016
Your holiday season has been hectic, no doubt. Catch up with an early gift from us: Our biweekly roundup of research news from Children's Hospital of Philadelphia comes with all the trimmings!
Published on
Jun 10, 2016
We like to highlight the whole range of research at The Children's Hospital of Philadelphia, from basic discoveries at the lab bench to clinical findings applied at the patient's bedside. But we have an abundance of updates to share today about the clinical side of research.
Published on
Dec 8, 2015
Researchers at The Children’s Hospital of Philadelphia reported their latest results from their studies of an investigational personalized cell therapy for a highly aggressive form of cancer, acute lymphoblastic leukemia (ALL).