Computational Biology | CHOP Research Institute

Computational Biology

Translational genomics in childhood cancers is the central focus of the Diskin Lab, which works to identify the inherited and acquired genetic drivers of cancer by combining quantitative computational methods with rigorous experimental approaches in the lab.

The Department of Biomedical and Health Informatics (DBHi) explores how data, technology, and knowledge converge to improve scientific research and patient care.

Dr. Xing is the Executive Director of the Department of Biomedical and Health Informatics, the Francis West Lewis Chair and director of the Center for Computational and Genomic Medicine at CHOP, and professor of Pathology and Laboratory Medicine at the University of Pennsylvania. His research focuses on computational biology and genomics of RNA processing and regulation.

xingyi [at]

Dr. Wang's research focuses on the development of bioinformatics methods to improve the understanding of the genetic basis of human diseases, and the integration of electronic health records and genomic information to facilitate genomic medicine on scale.

wangk [at]

Dr. Diskin's research is focused on translational genomics in childhood cancers. Her laboratory seeks to identify the genetic basis of childhood cancers by combining quantitative computational methods with rigorous "wet-lab" experimental approaches. In parallel, she has developed, and is applying, a proteogenomic approach to identify novel immunotherapeutic targets for high-risk and relapsed pediatric malignancies.

diskin [at]
Published on
Dec 3, 2018
An ambitious project is under way to create a holistic picture of pediatric health and disease by building a one-of-its-kind library based on all of the data generated at CHOP.
Published on
Nov 13, 2018
Synthesizing diverse data sets from many sources comes with vast opportunities to change pediatric medicine.
Published on
Apr 20, 2018
Learn about new grants and awards for our cancer researchers in this week's edition of In the News.