Antibiotics | CHOP Research Institute

Cornerstone Blog

NIH-funded Study Examines Interplay Between Immune Response and Antibiotic Dosage

Published on

Nov 20, 2023

Researchers Study Effects of Antibiotic Dosage on Immune Response

The NIH-funded study, PRESCRIBE, will help researchers understand how antibiotics affect organ function recovery and respiratory microbiota in children with sepsis.

Cornerstone Blog

Kidney Stones, Low-risk Deliveries, SARS-CoV-2 Seroprevalence, MIS-C, Leigh Syndrome

Published on

Jan 21, 2022

In The News: Kidney Stones, Low-risk Deliveries, SARS-CoV-2 Seroprevalence, MIS-C, Leigh Syndrome

Learn about novel findings and new funding from our Children’s Hospital of Philadelphia researchers.

Cornerstone Blog

A ‘Trojan Horse’ to the Rescue of Staph Infections

Published on

Jul 21, 2021

John Lab Establishes New Method to Develop Antibiotics

Audrey Odom John, MD, PhD, established a novel approach for developing effective antibiotics that are able to reach resistant bacteria.

Microbiome, Antibiotics and Growth Infant Cohort (MAGIC) Study

Microbiome, Antibiotics and Growth Infant Cohort Study

The MAGIC Study is looking at the microbiome as it develops during the first two years of life. It brings together expertise in the microbiome, antibiotic stewardship, immunology, neonatology, and infectious diseases to study the effect that health and environment have on the microbiome and growth.

Optimizing Vancomycin Therapy in Children

Vancomycin is a commonly administered antibiotic in critically ill children, but it can have unwanted side effects on the kidney (acute kidney injury).

POOPS

The purpose of this study is to determine how what you eat and drink (your diet), antibiotics you take, and the bacteria that live in your gut (microbiome) contribute to developing kidney stones.

Downes Laboratory

The Downes Lab studies pediatric antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) and pharmacoepidemiology with a focus on the relationship between antibiotic dosing/exposures and outcomes, including clinical cure, adverse events, and the development of antimicrobial resistance.

Cornerstone Blog

PA Device Consortium, Suicide Awareness, Future Fertility, Pneumonia Antibiotics, CAR Hosts Family Fun Research Day

Published on

Jan 25, 2019

From stem cell fertility research to staying alert for teen suicidal thoughts, this week’s research headlines spark conversations in the news.

Kevin Downes, MD

The research interests of Dr. Downes focus on antimicrobial clinical pharmacology and pharmacoepidemiology in children with a goal to identify novel approaches to optimize efficacy, minimize toxicity, and limit antimicrobial resistance from antibiotics.

E-mail:

downeskj [at] chop.edu

Sabrina A. Gmuca, MD, MSCE

Dr. Gmuca seeks to enhance the care of children with chronic musculoskeletal pain. Her current research addresses amplified musculoskeletal pain syndrome, which is a major public health issue because of its high prevalence, related socioeconomic burden, and associated risk of opioid exposure. Dr. Gmuca’s work aims to identify innovative strategies to improve long-term treatment outcomes for this patient population.

E-mail:

gmucas [at] chop.edu