T Cells | CHOP Research Institute

T Cells

Published on
Apr 23, 2024
Researchers from CHOP and Penn reveal that the microbiome and immune system play a key role in the non-genetic transfer of phenotypes to offspring.
Published on
Apr 10, 2024
Evan Weber, PhD, and a research team from CHOP and Stanford Medicine discovered that the protein FOXO1 plays a key role in regulating CAR T cells’ longevity and effectiveness.
Published on
Mar 18, 2024
Learn how the NAD metabolite controls how well T and B cells can detect their antigens, leading to quicker immune responses.
Published on
Mar 5, 2024
Two global teams are developing solid cancer drugs and understanding T-cell receptors.
Published on
Nov 13, 2023
Douglas C. Wallace, PhD, investigates the role of adaptive immunity in the etiology of Alzheimer’s disease (AD) and AD-related dementias.
Published on
Jul 27, 2023
In this Faculty Spotlight, Colin Conine, PhD, shares how receiving the Junior Faculty Award allows him to study how the microbiome and T cells regulate transgenerational epigenetic inheritance.
Published on
Dec 9, 2022
This week's news roundup features an outstanding science award, Highly Cited Researchers, and STAT Wunderkinds, along with new research about cancer risk with birth defects, epilepsy, and acute myeloid leukemia.

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

bailisw [at] chop.edu

The Oliver Lab focuses on revealing mechanisms governing T cell activation and protective immunity. Its goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.

All biological processes operate under biochemical constraints. The Bailis Lab aims to understand how metabolism controls the development and functional differentiation of the hematopoietic system by setting the biochemical potential of cells and tissues, using in vitro and in vivo CRISPR screening in primary immune cells.