Molecular Biology | CHOP Research Institute

Molecular Biology

The Cristancho Lab is interested in understanding the epigenetic mechanisms driving long-term neurodevelopmental disabilities from acquired prenatal and perinatal brain injury. Our goal is to develop novel therapies that can be used throughout the lifespan to improve outcomes for children.

Published on
Jan 3, 2022
Congratulations to Garrett Brodeur, MD, recipient of the American Society of Pediatric Hematology/Oncology Distinguished Career Award.

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

bailisw [at]

All biological processes operate under biochemical constraints. The Bailis Lab aims to understand how metabolism controls the development and functional differentiation of the hematopoietic system by setting the biochemical potential of cells and tissues, using in vitro and in vivo CRISPR screening in primary immune cells.

The Aquatic Zebrafish Core provides services using the small vertebrate zebrafish as a model for human disease and to study gene function.

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

cardinalec [at]
Published on
Nov 13, 2018
Synthesizing diverse data sets from many sources comes with vast opportunities to change pediatric medicine.