Epigenetics | CHOP Research Institute
 

Epigenetics

Wolpaw Laboratory

Adam Wolpaw Laboratory

Dr. Wolpaw’s laboratory seeks to develop an understanding of how tumor heterogeneity and epigenetics impact inflammatory signaling and immunotherapy responses in pediatric solid tumors with a goal of developing more efficacious, less toxic therapies to treat these devastating diseases.

Can a New High-throughput Array Accelerate DNA Methylation Characterization?

Published on
Jul 18, 2022
in Cornerstone Blog
New Array Accelerates DNA Methylation Characterization
CHOP researchers develop tool that accelerates DNA methylation characterization.

Center for Spatial and Functional Genomics

Center for Spatial and Functional Genomics

The Center for Spatial and Functional Genomics is focused on uncovering the correct functional context of variants identified by genome-wide association studies in order to translate these discoveries into meaningful benefits for pediatric care.

Spatial and Functional Genomics Research Affinity Group

Spatial and Functional Genomics Research Affinity Group

Uncovering the correct functional context of genetic variants to translate genome-wide association studies into meaningful benefits for pediatric care.

NIH New Innovator Award Supports Search for Answers in Splicing Codes and Cancer

Published on
Jan 13, 2022
in Cornerstone Blog
NIH Award Supports Search for Answers in Splicing Codes
Peter Choi, PhD, received the prestigious award for research into the hidden determinants of RNA splicing.

“Encourage Diversity of Thought:” Q&A With Marco Carpenter, PhD, Diversity Fellow

Published on
Dec 20, 2021
in Cornerstone Blog
Q&A With Marco D. Carpenter, PhD, Diversity Fellow
Dr. Carpenter’s research seeks to better understand how environmental factors affect the origins of disease via epigenetic modifications.

Faculty Spotlight: Naiara Akizu Lopez, PhD, Merges Research Passions

Published on
Aug 31, 2021
in Cornerstone Blog
Naiara Akizu Lopez, PhD, Merges Research Passions
Our August Faculty Spotlight scientist, Naiara Akizu Lopez, PhD, studies the genetic and epigenetic mechanisms of neurologic disorders in children.

What’s in a Sperm? Research Suggests, Stress, Diet, and Small RNAs

Published on
Aug 19, 2021
in Cornerstone Blog
Pew Scholar Studies Small RNAs in Sperm
Colin Conine, PhD, a 2021 Pew Scholar, studies small RNAs in sperm to understand how they influence traits of the offspring they produce.
Will Bailis, PhD
Will Bailis

Dr. Bailis aims to understand how metabolism underlies immunology and disease, by controlling the biochemistry of cells and tissues. His lab does so using in vitro and in vivo CRISPR engineering of primary human and mouse immune cells, with the goal of developing diet and metabolite based therapies.

E-mail:
bailisw [at] chop.edu

Wells Laboratory

Wells Lab

The Wells Laboratory studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.