Lysosomes | CHOP Research Institute
 

Lysosomes

Marks Laboratory

Marks Lab

The Marks Lab aims to dissect the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles and the assembly, delivery, and function of their contents, and to understand how these processes are impacted by genetic diseases.

Akizu Laboratory

Akizu Lab

Research in the Akizu Lab aims to better understand human brain complexity in health and disease, with the ultimate goal of uncovering therapeutic targets for pediatric neurodegenerative disorders.

Identifying Genetic Variants Associated With Skin Pigmentation May Offer Disease Insight

Published on
Nov 11, 2020
in Cornerstone Blog
Skin Pigmentation
Michael Marks, PhD, seeks to identify the genetic basis of normal human skin pigment variation, which could offer disease insight.

Grant Awarded to Study Gene Therapy for Disorders With Severe Brain Disease

Published on
Dec 4, 2019
in Cornerstone Blog
John Wolfe, VMD, PhD, is studying gene therapy methods to correct the brain disease of lysosomal storage disorders.
John Wolfe, VMD, PhD, receives grant to study gene therapy treatment for lysosomal storage disorders with severe disease of the brain.
Michael S. Marks, PhD
Michael S. Marks

Dr. Marks investigates the molecular mechanisms underlying the formation of cell type-specific lysosome-related organelles; the assembly, delivery and function of their contents; and how these processes are impacted by genetic diseases.

E-mail:
marksms [at] chop.edu
Naiara Akizu, PhD
Photo of Naiara Akizu

Dr. Akizu's research focuses on cerebellar ataxias and motoneuron disorders, with the specific goals of uncovering the particularities of these neuronal types, understanding disease mechanisms, and exploring treatment options.

E-mail:
aquizun [at] chop.edu