Ruffner Laboratory

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The Ruffner Lab focuses on the mechanisms of non-IgE mediated food allergies including eosinophilic esophagitis and food-protein induced enterocolitis syndrome. Their research studies involve a combination of in vitro mucosal models as well as detailed immunophenotyping of patients with food allergies.

Research Highlights

Ongoing work in the Ruffner Lab is focused on:

  • Epigenetic regulation of epithelial barrier function in eosinophilic esophagitis
  • Innate sensing and immunologic signaling in esophageal epithelial cells
  • Peripheral blood immune responses in patients with non-IgE mediated food allergies
  • The role of novel genes and pathways in the development of non-IgE mediated food allergy
  • Factors that affect the development of tolerance in non-IgE mediated food allergy.
Leader
Melanie A. Ruffner

Melanie A. Ruffner, MD, PhD