Results for Transcriptional Regulations

Dr. Mir develops and applies advanced fluorescence microscopy and single molecule imaging methods to study the dynamics of nuclear organization and transcriptional regulation during early embryonic development.

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

Dr. Cristancho is a child neurologist specializing in Fetal and Neonatal Neurology. Her research focuses on understanding the mechanisms that regulate the extent of disabilities some kids have after prenatal and neonatal brain injury. Her goal is to help develop novel therapeutic interventions.

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

Dr. De Leon-Crutchlow’s translational research program focuses on examining the pathophysiology of disorders of insulin regulation, identifying novel therapeutic targets, and developing new therapies for these conditions. The program approach includes patient-oriented research and bench research employing mouse models and primary islet cultures.

Dr. Gadue studies cell fate decisions, focusing on endoderm and mesoderm specification using human embryonic stem (ES) cells and induced pluripotent stem (iPS).

Dr. Liao is a pediatric plastic surgeon-scientist and the founding director of the Center for Craniofacial Innovation at Children's Hospital of Philadelphia. His research leverages convergent advances in fetal care, human genetics, and developmental biology to initiate first-in-child trials and treatments.

Matt Shapiro is a former high school science teacher who recently transitioned to a career in laboratory research. He is a research technician in the Wolpaw Lab where his research is focused on how lineage state impacts the transcriptional regulation of cGAS-STING signaling in neuroblastoma.