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Results for Transcription

1 - 10 of 114

Andrew D. Wells, PhD
Andrew D. Wells

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

E-mail:
wellsa [at] chop.edu
Mustafa Mir, PhD
Mustafa Mir, PhD

Dr. Mir develops and applies advanced fluorescence microscopy and single molecule imaging methods to study the dynamics of nuclear organization and transcriptional regulation during early embryonic development.

E-mail:
mirm [at] chop.edu
Véronique Lefebvre, PhD
Véronique Lefebvre

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

E-mail:
lefebvrev1 [at] chop.edu
Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Craig H. Bassing, PhD
Craig H. Bassing

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:
bassing [at] chop.edu
Gerd Blobel, MD, PhD
Gerd Blobel

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

E-mail:
blobel [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Liming Pei, PhD
Liming Pei

Dr. Pei's research aims to understand the molecular underpinnings of cardiac remodeling associated with cardiomyopathy and heart failure. He is particularly interested in two areas of cardiac remodeling: metabolic reprogramming, and secretion of heart-derived hormones to communicate with other organs.

E-mail:
peil [at] chop.edu
Daniel P. Kelly, MD
Daniel P. Kelly

Dr. Kelly’s research career began with deciphering the genetic basis of inborn errors in metabolism in children, followed by a series of breakthrough discoveries relevant to the diagnosis and treatment of common forms of heart failure in the general population.

E-mail:
dankelly [at] pennmedicine.upenn.edu
Evan Weber, PhD
Evan W. Weber

Dr. Weber is developing approaches to enhance CAR-T cell therapies for pediatric cancer by reprogramming T cells with improved durability and exhaustion resistance. His work will uncover molecular mechanisms that promote CAR-T cell exhaustion and identify new targets for therapeutic intervention.

E-mail:
weberew [at] chop.edu
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In this section

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  • Principal Investigator / Faculty (17)

Organizations

  • Center for Computational and Genomic Medicine (13)
  • Department of Pediatrics (11)
  • Department of Pathology and Laboratory Medicine (8)
  • Center for Childhood Cancer Research (7)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (7)
  • Department of Biomedical and Health Informatics (5)
  • Division of Allergy and Immunology (5)
  • Division of Infectious Diseases (5)
  • Division of Oncology (5)
  • Center for Mitochondrial and Epigenomic Medicine (4)
  • Division of Hematology (4)
  • Research Information Services (4)
  • Spatial and Functional Genomics Collaborative (4)
  • Center for Applied Genomics (3)
  • Center for Autism Research (3)
  • Center for Data-Driven Discovery in Biomedicine (3)
  • Division of Human Genetics (3)
  • Office of Academic Training and Outreach Programs (3)
  • PolicyLab (3)
  • Roberts Individualized Medical Genetics Center (3)
  • Blobel Laboratory (2)
  • Center for Injury Research and Prevention (2)
  • Center for Pediatric Clinical Effectiveness (2)
  • Department of Surgery (2)
  • Division of Cancer Pathobiology (2)
  • Division of Emergency Medicine (2)
  • Division of Gastroenterology, Hepatology, and Nutrition (2)
  • Division of Neonatology (2)
  • Maris Laboratory (2)
  • Mir Laboratory (2)
  • RIS Application Services (2)
  • RIS Infrastructure Services (2)
  • Bailis Laboratory (1)
  • Bernt Laboratory (1)
  • Bhoj Laboratory (1)
  • Biomedical Optical Devices to Monitor Cerebral Health (1)
  • Bosse Laboratory (1)
  • Center for Applied Genomics Laboratory (1)
  • Choi Laboratory (1)
  • Clinical Vector Core (1)
  • Davidson Laboratory (1)
  • DBHi Education and Faculty Development (1)
  • Division of Cardiology (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Nephrology (1)
  • Division of Neurology (1)
  • Division of Neurosurgery (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Enterprise Information Services (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Food Allergy Center (1)
  • Grant Laboratory (1)
  • Hamilton Laboratory (1)
  • Mossé Laboratory (1)
  • Pediatric Center of Excellence in Nephrology (1)
  • RIS Outreach Manager (1)
  • RIS Web Services (1)
  • Romberg Laboratory (1)
  • Spatial and Functional Genomics Research Affinity Group (1)
  • Stress Neurobiology Program (1)
  • Weitzman Laboratory (1)
  • Wells Laboratory (1)
  • Wolfson Family Laboratory for Clinical and Biomedical Optics (1)

In this section

Filter By

  • Principal Investigator / Faculty (17)

Organizations

  • Center for Computational and Genomic Medicine (13)
  • Department of Pediatrics (11)
  • Department of Pathology and Laboratory Medicine (8)
  • Center for Childhood Cancer Research (7)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (7)
  • Department of Biomedical and Health Informatics (5)
  • Division of Allergy and Immunology (5)
  • Division of Infectious Diseases (5)
  • Division of Oncology (5)
  • Center for Mitochondrial and Epigenomic Medicine (4)
  • Division of Hematology (4)
  • Research Information Services (4)
  • Spatial and Functional Genomics Collaborative (4)
  • Center for Applied Genomics (3)
  • Center for Autism Research (3)
  • Center for Data-Driven Discovery in Biomedicine (3)
  • Division of Human Genetics (3)
  • Office of Academic Training and Outreach Programs (3)
  • PolicyLab (3)
  • Roberts Individualized Medical Genetics Center (3)
  • Blobel Laboratory (2)
  • Center for Injury Research and Prevention (2)
  • Center for Pediatric Clinical Effectiveness (2)
  • Department of Surgery (2)
  • Division of Cancer Pathobiology (2)
  • Division of Emergency Medicine (2)
  • Division of Gastroenterology, Hepatology, and Nutrition (2)
  • Division of Neonatology (2)
  • Maris Laboratory (2)
  • Mir Laboratory (2)
  • RIS Application Services (2)
  • RIS Infrastructure Services (2)
  • Bailis Laboratory (1)
  • Bernt Laboratory (1)
  • Bhoj Laboratory (1)
  • Biomedical Optical Devices to Monitor Cerebral Health (1)
  • Bosse Laboratory (1)
  • Center for Applied Genomics Laboratory (1)
  • Choi Laboratory (1)
  • Clinical Vector Core (1)
  • Davidson Laboratory (1)
  • DBHi Education and Faculty Development (1)
  • Division of Cardiology (1)
  • Division of Endocrinology and Diabetes (1)
  • Division of Nephrology (1)
  • Division of Neurology (1)
  • Division of Neurosurgery (1)
  • Division of Orthopaedic Surgery (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • Division of Rheumatology (1)
  • Enterprise Information Services (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Food Allergy Center (1)
  • Grant Laboratory (1)
  • Hamilton Laboratory (1)
  • Mossé Laboratory (1)
  • Pediatric Center of Excellence in Nephrology (1)
  • RIS Outreach Manager (1)
  • RIS Web Services (1)
  • Romberg Laboratory (1)
  • Spatial and Functional Genomics Research Affinity Group (1)
  • Stress Neurobiology Program (1)
  • Weitzman Laboratory (1)
  • Wells Laboratory (1)
  • Wolfson Family Laboratory for Clinical and Biomedical Optics (1)
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