Results for Transcription

1 - 10 of 129

Dr. Wells studies the genetic, epigenetic, and transcriptional mechanisms that control T lymphocyte immunity and tolerance.

E-mail:

wellsa [at] chop.edu

Mustafa Mir, PhD

Dr. Mir develops and applies advanced fluorescence microscopy and single molecule imaging methods to study the dynamics of nuclear organization and transcriptional regulation during early embryonic development.

E-mail:

mirm [at] chop.edu

Véronique Lefebvre, PhD

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

E-mail:

lefebvrev1 [at] chop.edu

Christopher J. Cardinale, MD, PhD

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:

cardinalec [at] chop.edu

Craig H. Bassing, PhD

Dr. Bassing's research program focuses on the genetic, epigenetic, and biochemical mechanisms by which mammals develop their immune systems while suppressing autoimmunity and genomic aberrations that cause leukemia or lymphoma.

E-mail:

bassing [at] chop.edu

Gerd Blobel, MD, PhD

Dr. Blobel investigates the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He is gearing his basic science discoveries towards genetic and epigenetic treatment modalities. In addition, Dr. Blobel is interested in mechanism of epigenetic memory.

E-mail:

blobel [at] chop.edu

Kai Tan, PhD

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:

tank1 [at] chop.edu

Liming Pei, PhD

Dr. Pei's research aims to understand the molecular underpinnings of cardiac remodeling associated with cardiomyopathy and heart failure. He is particularly interested in two areas of cardiac remodeling: metabolic reprogramming, and secretion of heart-derived hormones to communicate with other organs.

E-mail:

peil [at] chop.edu

Daniel P. Kelly, MD

Dr. Kelly’s research career began with deciphering the genetic basis of inborn errors in metabolism in children, followed by a series of breakthrough discoveries relevant to the diagnosis and treatment of common forms of heart failure in the general population.

E-mail:

dankelly [at] pennmedicine.upenn.edu

Natalie A. Terry, MD, PhD

Dr. Terry's research focuses on the mechanisms of malabsorption in congenital diarrheal disorders and short bowel syndrome.

E-mail:

terryn [at] chop.edu