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Results for Stem Cells

1 - 10 of 196

Paul Gadue, PhD
Paul Gadue

Dr. Gadue studies cell fate decisions, focusing on endoderm and mesoderm specification using human embryonic stem (ES) cells and induced pluripotent stem (iPS).

E-mail:
gaduep [at] chop.edu
Wei Tong, PhD
Wei Tong

Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.

E-mail:
tongw [at] chop.edu
Deborah L. French, PhD
Deborah French

Dr. French came to CHOP in 2008 to establish the Human Pluripotent Stem Cell Core in the Center for Cellular and Molecular Therapeutics. She is an internationally recognized researcher involved in multi-investigator teams that utilize pluripotent stem cells for modeling human disease to study mechanism, development, and establish new therapeutic modalities.

E-mail:
frenchd [at] chop.edu
Timothy S. Olson, MD, PhD
Timothy S. Olson Headshot

Dr. Olson aims to improve diagnostics and treatment of bone marrow failure (BMF) syndromes, and to improve clinical hematopoietic stem cell transplantation (HSCT) outcomes. He conducts clinical trials of HSCT for non-malignant hematologic diseases. His laboratory explores both basic and translational research focused on genomics of BMF and the impact of BMF on hematopoietic niche function during HSCT.

E-mail:
olsont [at] chop.edu
Peter Kurre, MD
Peter Kurre

Dr. Kurre's laboratory has longstanding expertise in Fanconi Anemia (FA), a genetic condition with prominent hematologic complications. With training in transplantation and hematopoietic stem cell biology, he hopes to improve the understanding of the progressive hematopoietic failure in patients with bone marrow failure and FA, broaden diagnostic approaches, and develop next generation therapies.

E-mail:
kurrep [at] chop.edu
Alan W. Flake, MD
Alan W. Flake

Dr. Flake is a general pediatric surgeon with a clinical and research focus on prenatal treatment ranging from the fetal surgical repair of anatomic anomalies to prenatal stem cell and gene therapy. He has extensive experience in developing rodent, canine, and sheep models for in utero transplantation and for investigating fetal surgery for anatomic malformations.

E-mail:
flake [at] chop.edu
Stella T. Chou, MD
Stella T. Chou, MD

Dr. Chou focuses on regenerative blood cellular therapy, the mechanisms of normal human hematopoietic development, and the pathophysiology of pediatric hematologic diseases.

E-mail:
chous [at] chop.edu
Véronique Lefebvre, PhD
Véronique Lefebvre

Dr. Lefebvre investigates the genetic mechanisms that generate the diversity of cell types composing the body. Her emphasis is on deciphering how proteins called SOX transcription factors specify stem cells and highly specialized cells in the skeleton, how changes in these factors cause skeletal diseases, and how these factors also control other processes, including brain development and intellectual disability diseases.

E-mail:
lefebvrev1 [at] chop.edu
Stephan A. Grupp, MD, PhD
Stephan A. Grupp

Dr. Grupp develops and conducts preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric immunotherapy trials, and in the manufacture and use of cellular therapeutics in preclinical, good manufacturing practices, and clinical trial settings. Dr. Grupp leads most CTL019 (CD19 CAR) clinical trials, and his colleagues are the global leaders in highly active CAR T cell therapy.

E-mail:
grupp [at] chop.edu
Xilma R. Ortiz-Gonzalez, MD, PhD
Xilma R. Ortiz-Gonzalez

Dr. Ortiz-Gonzalez is a physician-scientist specializing in pediatric neurogenetics. Her clinical work focuses on finding a unifying genetic diagnosis for children with rare neurodevelopmental disorders. Her research is informed by her patients and focuses on understanding how genetic changes, in particular those affecting mitochondrial function, cause disease so we can develop better treatments for these children in the future.

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In this section

Filter By

  • Principal Investigator / Faculty (25)
  • Researcher / Lab Personnel (8)

Organizations

  • Department of Pediatrics (23)
  • Division of Oncology (14)
  • Center for Injury Research and Prevention (12)
  • Division of Hematology (11)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (11)
  • Center for Autism Research (9)
  • Center for Childhood Cancer Research (9)
  • Anderson Laboratory (7)
  • Center for Applied Genomics (7)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (7)
  • Human Pluripotent Stem Cell Core (6)
  • Cancer Immunotherapy (CAR-T) (5)
  • Center for Mitochondrial and Epigenomic Medicine (5)
  • Comprehensive Bone Marrow Failure Center (5)
  • Department of Biomedical and Health Informatics (5)
  • Division of Allergy and Immunology (5)
  • Division of Human Genetics (5)
  • Division of Infectious Diseases (5)
  • Lifespan Brain Institute (5)
  • Office of Academic Training and Outreach Programs (5)
  • Center for Computational and Genomic Medicine (4)
  • Department of Anesthesiology and Critical Care Medicine (4)
  • Mitochondrial Medicine (4)
  • Department of Pathology and Laboratory Medicine (3)
  • Division of Gastroenterology, Hepatology, and Nutrition (3)
  • Division of Neonatology (3)
  • Kurre Laboratory (3)
  • Spatial and Functional Genomics Collaborative (3)
  • Akizu Laboratory (2)
  • Bernt Laboratory (2)
  • Center for Applied Genomics Laboratory (2)
  • Center for Child Injury Prevention Studies (2)
  • Department of Radiology (2)
  • Division of Cardiology (2)
  • Division of Endocrinology and Diabetes (2)
  • Division of Neurology (2)
  • Hamilton Laboratory (2)
  • Heuckeroth Laboratory (2)
  • Inflammatory Bowel Disease Center (2)
  • PennCHOP Microbiome Program (2)
  • PolicyLab (2)
  • Rivella Laboratory (2)
  • Roberts Individualized Medical Genetics Center (2)
  • Vaccine and Treatment Evaluation Unit (2)
  • Beckwith-Wiedemann Syndrome Program of Excellence (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for Pediatric Clinical Effectiveness (1)
  • Center for Violence Prevention (1)
  • CHOP Postdoctoral Alliance (1)
  • Chou Laboratory (1)
  • Clinical Vector Core (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Davidson Laboratory (1)
  • DBHi Bioinformatics (1)
  • Department of Surgery (1)
  • Division of Adolescent Medicine (1)
  • Division of Cell Pathology (1)
  • Division of Emergency Medicine (1)
  • Division of Neurosurgery (1)
  • Division of Urology (1)
  • eMERGE (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Food Allergy Center (1)
  • Goldberg Laboratory (1)
  • IDDRC Preclinical Models Core (1)
  • Immune Dysregulation Program (1)
  • Maris Laboratory (1)
  • MetaCHOP Research Affinity Group (1)
  • Minds Matter Concussion Program (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
  • Wallace Laboratory (1)

In this section

Filter By

  • Principal Investigator / Faculty (25)
  • Researcher / Lab Personnel (8)

Organizations

  • Department of Pediatrics (23)
  • Division of Oncology (14)
  • Center for Injury Research and Prevention (12)
  • Division of Hematology (11)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (11)
  • Center for Autism Research (9)
  • Center for Childhood Cancer Research (9)
  • Anderson Laboratory (7)
  • Center for Applied Genomics (7)
  • Department of Child and Adolescent Psychiatry and Behavioral Sciences (7)
  • Human Pluripotent Stem Cell Core (6)
  • Cancer Immunotherapy (CAR-T) (5)
  • Center for Mitochondrial and Epigenomic Medicine (5)
  • Comprehensive Bone Marrow Failure Center (5)
  • Department of Biomedical and Health Informatics (5)
  • Division of Allergy and Immunology (5)
  • Division of Human Genetics (5)
  • Division of Infectious Diseases (5)
  • Lifespan Brain Institute (5)
  • Office of Academic Training and Outreach Programs (5)
  • Center for Computational and Genomic Medicine (4)
  • Department of Anesthesiology and Critical Care Medicine (4)
  • Mitochondrial Medicine (4)
  • Department of Pathology and Laboratory Medicine (3)
  • Division of Gastroenterology, Hepatology, and Nutrition (3)
  • Division of Neonatology (3)
  • Kurre Laboratory (3)
  • Spatial and Functional Genomics Collaborative (3)
  • Akizu Laboratory (2)
  • Bernt Laboratory (2)
  • Center for Applied Genomics Laboratory (2)
  • Center for Child Injury Prevention Studies (2)
  • Department of Radiology (2)
  • Division of Cardiology (2)
  • Division of Endocrinology and Diabetes (2)
  • Division of Neurology (2)
  • Hamilton Laboratory (2)
  • Heuckeroth Laboratory (2)
  • Inflammatory Bowel Disease Center (2)
  • PennCHOP Microbiome Program (2)
  • PolicyLab (2)
  • Rivella Laboratory (2)
  • Roberts Individualized Medical Genetics Center (2)
  • Vaccine and Treatment Evaluation Unit (2)
  • Beckwith-Wiedemann Syndrome Program of Excellence (1)
  • Cell and Gene Therapy Collaborative (1)
  • Center for Data-Driven Discovery in Biomedicine (1)
  • Center for Pediatric Clinical Effectiveness (1)
  • Center for Violence Prevention (1)
  • CHOP Postdoctoral Alliance (1)
  • Chou Laboratory (1)
  • Clinical Vector Core (1)
  • Comprehensive Center for the Cure of Sickle Cell Disease and Other Red Blood Cell Disorders (1)
  • Davidson Laboratory (1)
  • DBHi Bioinformatics (1)
  • Department of Surgery (1)
  • Division of Adolescent Medicine (1)
  • Division of Cell Pathology (1)
  • Division of Emergency Medicine (1)
  • Division of Neurosurgery (1)
  • Division of Urology (1)
  • eMERGE (1)
  • Epilepsy NeuroGenetics Initiative (ENGIN) (1)
  • Fetal Biology and Therapy Research Affinity Group (1)
  • Food Allergy Center (1)
  • Goldberg Laboratory (1)
  • IDDRC Preclinical Models Core (1)
  • Immune Dysregulation Program (1)
  • Maris Laboratory (1)
  • MetaCHOP Research Affinity Group (1)
  • Minds Matter Concussion Program (1)
  • Pennsylvania Pediatric Medical Device Consortium (1)
  • Translational Research Program in Pediatric Orthopaedics (1)
  • Wallace Laboratory (1)
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