Dr. Thomas-Tikhonenko has a long-standing interest in the pathobiology of solid and hematopoietic malignancies, in particular lymphomas and leukemias and other cancers driven by MYC overexpression. Within that research space, his studies focus mainly (but not exclusively) on RNA-based regulatory mechanisms, such as microRNAs and alternative mRNA splicing.
"Bold" is perhaps the best word to describe this week's roundup of Research Institute news, as Children's Hospital of Philadelphia nurses and investigators alike made headlines for their experimental work in pediatric CAR T-cell therapy: a cancer-fighting immunotherapy treatment that aims to re-engineer a patient's own T cells to detect and destroy tumor cells.
Many scientific endeavors take place quietly behind laboratory walls, but this week's In the News items are worth shouting about. A genomics expert will share his insights about CHOP's precision medicine experience at the inaugural Advances in Genome Biology and Technology meeting. Driving safety researchers asked teens to speak up about their perceptions of passenger distraction.