Dr. Zemel's overall research program aims to improve the understanding of lifelong health and how it relates to childhood antecedents of physical growth and maturation, body composition, population ancestry/genetics, and lifestyle factors. Such insight has practical implications for disease prevention and lifelong wellness, as well as broader scientific implications for understanding human plasticity and evolution.
Dr. Mitchell's research aims to explain variations in childhood growth patterns related to the causes and prevention of diseases in later life. This includes studying the impact of behaviors and genes on body composition during development, especially childhood sleep and physical activity behavior.
Dr. Kalish's research focuses on understanding the molecular and epigenetic mechanisms that contribute to the predisposition to cancer that is characteristic of pediatric patients with rare imprinted gene disorders, including the overgrowth disorder Beckwith-Wiedemann syndrome (BWS).
Bone mineral accrual doesn't keep pace with height growth prior to adolescence, according to a national study. After a teenager reaches adult height, bone mineral accrual tends to play catch-up: Roughly 10 percent of bone mass continues to accumulate after height growth is complete. The study findings also suggest that bone growth is site-specific, with bone mineral density developing at different rates in different parts of the skeleton.
Editor's Note: This occasional blog series features stories of CHOP research heroes who have participated in clinical research studies. Without the generosity and dedication of families, patients, and members of the public who take the time to be a part of research, many trials would not succeed.
Six-year-old Brynn Clare Connor has never spoken a word in her life, but