Dr. Getz develops and applies advanced methods to enable epidemiologic research that aims to optimize the treatment and supportive care of children with cancer by balancing the therapeutic benefits and toxicity risks with an emphasis in cardio-oncology.
The Downes Lab studies pediatric antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) and pharmacoepidemiology with a focus on the relationship between antibiotic dosing/exposures and outcomes, including clinical cure, adverse events, and the development of antimicrobial resistance.
The purpose of this study is to see if a new investigational drug (Upadacitinib) is safe and well tolerated and also to determine the appropriate dose for subjects with polyarticular course juvenile arthritis (pcJIA).
The Investigational Drug Service (IDS) component of Children’s Hospital of Philadelphia's Department of Pharmacy Services complements the institution's clinical research mission in advancing new therapeutic modalities.
The Comparative Medicine Services Core partners with and guides investigators through the process of translating their wet bench research into clinical care to improve the lives of patients and families.
Revolutionizing our understanding of the genetic causes and mechanisms of hyperinsulinism, developing diagnostic tools for a precision-medicine approach to treatment, and discovering new treatment options.
The Cancer Pharmacology Laboratory supports clinical trials of new mechanistically targeted and immune-based anticancer drugs by conducting pre-clinical and clinical pharmacology studies of the agents. The lab also studies conventional anticancer drugs to develop more rational and effective dosing methods, and the lab team is developing ci