Results for Nuclear Organization

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Mustafa Mir, PhD
Mustafa Mir, PhD

Dr. Mir develops and applies advanced fluorescence microscopy and single molecule imaging methods to study the dynamics of nuclear organization and transcriptional regulation during early embryonic development.

E-mail:
mirm [at] chop.edu
Frederick D. Grant, MD
Frederick D. Grant, MD

Dr. Grant is an attending pediatric radiologist in the Divisions of Body Imaging and Nuclear Medicine of the Department of Radiology.

E-mail:
grantf [at] chop.edu
Dah-Jyuu Wang, PhD
Dah-Jyuu Wang

Dr. Wang works on biomarker identification using multiparametric magnetic resonance imaging and homo- and hetero-nuclear spectroscopy techniques for pediatric disease research including  tumors, iron overload, cystic fibrosis, muscular dystrophy, autism, mitochondrial, Gaucher’s, and Canavan’s diseases.

E-mail:
wangd [at] chop.edu

Tableside Chat About Mitochondria Leads to Gates Foundation Grant for COVID-19 Research

Published on
Mar 2, 2023
in Cornerstone Blog
Tableside Chat Leads to Gates Foundation Grant for CHOP
With a grant from the Gates Foundation, CHOP researchers are working to determine the importance of mitochondria DNA variation in COVID-19 severity.

In the News: Foundational Gift, Gates Grant, Community-engaged Research

Published on
Feb 17, 2023
in Cornerstone Blog
In the News: Foundational Gift, Community Partnerships
In this news roundup, learn how CHOP researchers are advancing research for neurological diseases and engaging in community collaborative research.

From ‘Generation to Generation:’ Faculty Spotlight With Itzhak Nissim, PhD

Published on
Apr 27, 2022
in Cornerstone Blog
Faculty Spotlight With Itzhak Nissim, PhD
Dr. Nissim studies the relationship of the metabolome and the fluxome to the genome in normal and disease states.

In the News: Mitochondrial Gene Variance, Killing Cancer Cells, NICU Stress Effects, Visually Impaired Driver Safety

Published on
Mar 22, 2019
in Cornerstone Blog
CHOP Research In the News
In this week’s roundup, our researchers make impactful discoveries in genetics, cancer treatment, and more.

Gene Behind Long-Recognized Mitochondrial Disease Has Highly Varied Effects

Published on
Mar 12, 2019
in Press Releases
For more than two decades, mutations in a gene located in the DNA of mitochondria have been classified as a mitochondrial disease and linked to a particular set of symptoms. However, according to new findings from researchers at Children's Hospital of Philadelphia (CHOP), mutations in this gene, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought.

An Existing Drug May Have Therapeutic Potential in Mitochondrial Disease

Published on
Feb 26, 2019
in Press Releases
New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders—complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients.

In the News: Brain Cancer Gene Therapy, 2019 Eagles Autism Challenge, Mitochondrial DNA in Cardiomyopathy, Kids First DRC, Device Symposium

Published on
Sep 21, 2018
in Cornerstone Blog
CHOP Research In the News
From novel findings about the role of mtDNA in heart disease to news about the 2nd Eagles Autism Challenge, we've got the latest headlines.
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