Dr. Offit is director of the Vaccine Education Center at CHOP and an internationally recognized expert in the fields of virology and immunology. He is co-inventor of a landmark vaccine achievement for the prevention of rotavirus gastroenteritis.
Dr. Silverman studies the fundamental aspects of early-life commensal microbes that influence immune system development and function. He discovered that the MHC-II E molecule prevents type 1 diabetes by shaping the intestinal microbiota early in life.
Leveraging innovative experimental methodology, computational approaches, and molecular tools to better understand immune system development, immune response to microorganisms, and mucosal immunology.
The Ruffner Lab's long-term goal is to understand how the interactions between the immune system and mucosal barrier are altered in patients with food allergies.
