Results for Molecular Chaperones

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Ronald C. Rubenstein, MD, PhD
Ronald C. Rubenstein

Dr. Rubenstein's research focuses on basic and translational studies of novel means to improve outcomes in cystic fibrosis. He initially focused on correcting the dysfunction of mutant cystic fibrosis transmembrane conductance regulator (CFTR) proteins, which led him to study how molecular chaperones regulate the biogenesis and trafficking of CFTR and other proteins that are relevant to cystic fibrosis.

E-mail:
rubensteinr [at] chop.edu

In the News: Firearms Brief, Pandemic Births, Friedreich's Ataxia Center Funding, 'Voices on Diversity'

Published on
Dec 18, 2020
in Cornerstone Blog
In the News
This week’s In the News features firearms research, stillbirths during COVID, donations to the Friedreich’s Ataxia Center of Excellence, and postdocs highlighted for diversity.

Snapshot Science: Why is Targeting GRP75 a Novel Strategy for Treatment of Friedreich Ataxia?

Published on
Jan 14, 2019
in Cornerstone Blog
Friedreich ataxia
Our latest Snapshot Science shares new insights about mitochondrial molecular chaperone GRP75 and its role in the rare disease Friedreich ataxia.

Mechanistic Molecular Immunology Lab

Mechanistic Molecular Immunology Lab

The Mechanistic Molecular Immunology Lab integrates cutting-edge structural biology and biochemistry tools with functional immunoassays to understand the molecular basis of immune responses to viral infections and tumors, with an emphasis on the development of novel protein-based therapeutics.

Rubenstein Laboratory

Rubenstein Laboratory

The Rubenstein Lab conducts basic and translational research on novel means to improve cystic fibrosis outcomes.

Argon Laboratory

The unfolded protein response (UPR) is an essential signaling network that determines life or death of stressed cells and tissues.  The IRE1 sensor of UPR responds to metabolic stress through four distinct activities, and research in the Argon Laboratory centers on determining which stress condition induces each activity and how they are in

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