Dr. Weiss' research focuses on epidemiology of pediatric sepsis and mitochondrial dysfunction in sepsis-associated organ injury. The driving hypothesis for his research is that alterations in mitochondrial bioenergetics contribute to organ injury and immune dysregulation in a subset of children with sepsis.
Dr. Marsh's research program focuses on understanding how changes in brain development lead to epilepsy, intellectual disability, and autism. He combines molecular and physiological tools in mouse models to ask questions about the interaction of normal development with single gene mutations to determine how the brain responds to perturbations in development.
Dr. Nissim is a biochemist and a pioneer in the application of stable isotopes, mass spectrometry, and nuclear magnetic resonance to study metabolome and fluxome and their coupling to genome in normal and disease states. His long-standing interest focuses on understanding the cause, mechanisms, and outcome of metabolic disorders.