Dr. Oliver investigates the mechanisms governing T cell activation and protective immunity. Her goal is to define mechanisms that, when dysregulated, result in autoimmunity or allergic disorders like asthma.
Piotr Jung is a postdoctoral fellow in the Wolpaw Lab focused on modeling lineage heterogeneity in neuroblastoma. Jung is interested in how three-dimensional culture methods impact cell state.
Matt Shapiro is a former high school science teacher who recently transitioned to a career in laboratory research. He is a research technician in the Wolpaw Lab where his research is focused on how lineage state impacts the transcriptional regulation of cGAS-STING signaling in neuroblastoma.
John M. Maris, MD, is leading a pediatric immuno-oncology Center for Discovery and Development of Optimal Immunotherapeutic Strategies for Childhood Cancers with support from the NCI Moonshot Initiative.
Differences in mitochondrial function are a major factor in understanding the origins of autism spectrum disorders (ASD), according to a new study led by Douglas Wallace, PhD, director of the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia, that points way back to genetic vulnerabilities accumulated during ancient human migrations.
The term “stem cell,” stammzellen, was first used in 1868 by the German biologist Ernst Haeckel to describe the original, unicellular progenitor from which Dr. Haekel supposed all multicellular plant and animal life might have descended.
The Wolpaw Lab's work has centered on the childhood tumor, neuroblastoma. Neuroblastoma cells can exist in one of two epigenetic or lineage states, an "adrenergic" state that comprises the majority of the bulk tumor and tends to be responsive to chemotherapy, and a "mesenchymal" state that is a more minor subpopulation and more resistant to chemotherapy.
