Dr. Foster’s current research focuses on immunotherapy for pediatric solid and brain tumors. Specifically she is investigating chimeric antigen receptor (CAR) T cell therapy for neuroblastoma, high-grade gliomas, medulloblastomas, diffuse intrinsic pontine gliomas, and other brain tumors. The goals of her research are to develop pre-clinical CAR T cells for translation into clinical trials to help these devastating tumors.
Dr. De Raedt researches pediatric high grade glioma development and aims to understand the involvement of crucial pathways. He investigates pathway interaction, and explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models. This allows Dr. De Raedt and his team to perform novel pre-clinical studies that can lead to clinical trials.
Dr. Cole is a pediatric neuro-oncologist who has dedicated her career to translational and clinical research, combining her expertise in molecular pathology, cancer genomics, and developmental therapeutics to identify novel treatments for children with cancer.
Research in the De Raedt Lab centers on pediatric high-grade glioma development and aims to understand the involvement of crucial pathways that drive these pediatric brain tumors. The lab investigates pathways interaction, and it explores ways to develop therapies through analyzing human tumors, performing cellular studies, and developing accurate mouse models. This allows the lab team to perform novel preclinical studies that can lead to clinical trials.
Research in the Cole Lab focuses on identifying therapeutic vulnerabilities within molecularly defined subsets of pediatric central nervous system malignancies. The long-term goal of the lab is to identify effective therapies and improve the cure rate of children with malignant brain tumors.