Results for Gene Expression Analysis

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Christopher J. Cardinale, MD, PhD
Christopher J. Cardinale

Dr. Cardinale's research is focused on understanding the mechanisms of gene expression and gene regulation in autoimmune diseases, including inflammatory bowel disease, type 1 diabetes, and systemic sclerosis. He uses data from large-scale genomic studies to identify disease-causing genetic variants and functionally explore the target genes of those variants.

E-mail:
cardinalec [at] chop.edu
Kai Tan, PhD
Kai Tan

Dr. Tan studies transcriptional regulation during normal development and disease. This involves the interplay of multiple transcription and epigenetic factors in a 3D chromosomal environment. Using experimental genomics and computational modeling, Dr. Tan investigates transcriptional regulatory networks underlying embryonic hematopoiesis, T cell differentiation, and pediatric leukemia.

E-mail:
tank1 [at] chop.edu
Katherine L. Helbig, MS, LCGC
Katherine L. Helbig

Katherine Helbig’s research focuses on identifying new genetic causes of epilepsy and understanding how genetic variation leads to seizures. An additional research focus is improving access to genetic services for people with epilepsy and investigating the impact of genetics on health outcomes.

E-mail:
helbigk [at] chop.edu

In the News: Mental Health, Fontan Circulation, Social Impairment, Gene Therapy

Published on
Aug 20, 2021
in Cornerstone Blog
In The News
This week in the news, we share findings on Fontan circulation side effects, pediatric brain tumor survivorship, gene therapy, and more.

Celebrate Diversity Month: Q&A With Featured Research Trainee Mallory Perry, PhD, RN

Published on
Apr 8, 2021
in Cornerstone Blog
Celebrate Diversity Month: Q&A With Mallory Perry, PhD, RN
In this Q&A, Dr. Perry discusses her research, her experience as a CHOP Diversity Fellow, and the importance of Celebrate Diversity Month.

Researchers Develop Long-read-based Strategy for circRNA Analysis

Published on
Jan 15, 2021
in Cornerstone Blog
Researchers Develop Long-read-based Strategy for circRNA Analysis
Researchers eager to understand circRNAs’ unique set of properties and their functional roles.

In The News: Extremely Small Babies, Concussed Adolescent Drivers, Beckwith-Wiedemann Syndrome, Children With Severe Sepsis

Published on
Jan 8, 2021
in Cornerstone Blog
In the News
This week’s research news features CHOP’s participation in a study that found outcome disparities by race/ethnicity in children with severe sepsis.

Snapshot Science: Can a New Computational Method Help to Prioritize Noncoding Mutations that Disrupt Gene Expression in Pediatric Cancer?

Published on
Aug 3, 2020
in Cornerstone Blog
Snapshot Science: New Computational Method for Noncoding Mutations
Snapshot Science sums up a new computational method to identify noncoding mutations in pediatric cancer.

Snapshot Science: Does In Utero BPA Exposure Affect Genes Related to Development of Diabetes and Obesity in Amniocytes?

Published on
Feb 21, 2020
in Cornerstone Blog
BPA in Pregnancy
Exposure to BPA in utero during critical periods of fetal development linked to obesity and diabetes.

In the News: Pre-transplant Communication, Working Memory and Driving, Master Regulator Gene in Schizophrenia, Girls’ Concussion Care, Baby Brain Development

Published on
Sep 20, 2019
in Cornerstone Blog
CHOP Research In the News
In this week’s recap, our researchers share discoveries in driving safety, concussion recovery, schizophrenia treatment, and more.
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