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Results for Factor VIII

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Benjamin J. Samelson-Jones, MD, PhD
Benjamin J. Samelson-Jones

Dr. Samelson-Jones is a pediatric hematologist dedicated to improving the lives of children with bleeding and clotting disorders. His research focuses on gene therapy for hemophilia, the biochemical basis of coagulation, and the immune responses to hemophilia therapies.

E-mail:
samelsonjonesb [at] chop.edu
Denise E. Sabatino, PhD
Denise E. Sabatino

The research in the Sabatino Laboratory is focused on hemophilia, an inherited bleeding disorder. The interests of the laboratory include the study of variants of coagulation factor VIII to understand the biochemical properties of these proteins and to identify novel variants with enhanced function, and the development of gene-based therapeutic approaches for treating hemophilia.

E-mail:
sabatinod [at] chop.edu
Lindsey A. George, MD
Lindsey A. George

Dr. George's basic and clinical research interests are in the development of novel therapeutics for hemophilia. Her basic science laboratory studies the molecular basis of coagulation, and she is the principal investigator of ongoing hemophilia A and B gene therapy trials.

E-mail:
georgel [at] chop.edu
Rodney M. Camire, PhD
Rodney M. Camire Headshot

Dr. Camire's research focuses on understanding the components of the blood coagulation system, how they interface with activated cells, and how disturbances in their function lead to bleeding and thrombosis. He is also interested in developing novel therapeutic approaches (protein, gene-based, small molecule) to mitigate these events, which are major causes of morbidity and mortality worldwide.

E-mail:
camire [at] chop.edu

In The News: MIS-C, Antibody Treatment for Eosinophilic Esophagitis, ASH 2022

Published on
Jan 6, 2023
in Cornerstone Blog
Our Scientists’ Research Highlighted In the News
See highlights of work by Children’s Hospital of Philadelphia researchers that is leading to novel findings.

Research Shows Multiyear Factor VIII Expression After Hemophilia A Gene Therapy

Published on
Nov 19, 2021
in Cornerstone Blog
A one-time treatment with an adeno-associated viral vector demonstrated safe, sustained factor VIII expression for patients with hemophilia A.
Dr. Lindsey George and colleagues report safe and sustained expression following hemophilia A gene therapy.

CHOP-led Study Shows Novel Gene Therapy for Hemophilia A Leads to Sustained Expression of Clotting Factor and Reduced Bleeding Events

Published on
Nov 17, 2021
in Press Releases
Results from multicenter study are first to show improved production of coagulation factor VIII over prolong period, reducing bleeding events.

From Mentors to Making it Your Own: Inspiration From Women in STEM

Published on
Mar 8, 2021
in Cornerstone Blog
Inspiration from Women in STEM at CHOP
Nominated by their Centers of Emphasis, women in STEM share what drives them, their words of wisdom, and why they do what they do.

In the News: 22q, Mentoring Award, Neonatal E. coli, Gene Therapy, Siegel Award

Published on
Nov 20, 2020
in Cornerstone Blog
In the News
This week in the news: New awards for our scientists and findings for antibiotic stewardship, gene therapy, and 22q11.2 deletion syndrome.

Our Most Read Stories of 2018 Celebrate Diversity, Data, and Discovery

Published on
Dec 31, 2018
in Cornerstone Blog
Photo of family watching winter fireworks
We peeked into our data to see which research stories captivated our readers the most in 2018: Here are our top six.
1 - 10 of 22

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In this section

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  • Principal Investigator / Faculty (4)

Organizations

  • Division of Hematology (12)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (8)
  • Department of Pediatrics (3)
  • Center for Childhood Cancer Research (2)
  • Center for Computational and Genomic Medicine (2)
  • Center for Injury Research and Prevention (2)
  • Arruda Laboratory (1)
  • Camire Laboratory (1)
  • Center for Applied Genomics (1)
  • Center for Autism Research (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for the Investigation of Factor FVIII Immunogenicity (1)
  • Clinical Futures (1)
  • Clinical In Vivo Gene Therapy (1)
  • Division of Allergy and Immunology (1)
  • Division of Cardiology (1)
  • Division of Human Genetics (1)
  • Division of Neonatology (1)
  • Division of Oncology (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • George Laboratory (1)
  • Margaritis Laboratory (1)
  • Novel Therapeutics for Bleeding Disorders (1)
  • Office of Academic Training and Outreach Programs (1)
  • PolicyLab (1)
  • Samelson-Jones Laboratory (1)

In this section

Filter By

  • Principal Investigator / Faculty (4)

Organizations

  • Division of Hematology (12)
  • Raymond G. Perelman Center for Cellular and Molecular Therapeutics (8)
  • Department of Pediatrics (3)
  • Center for Childhood Cancer Research (2)
  • Center for Computational and Genomic Medicine (2)
  • Center for Injury Research and Prevention (2)
  • Arruda Laboratory (1)
  • Camire Laboratory (1)
  • Center for Applied Genomics (1)
  • Center for Autism Research (1)
  • Center for Mitochondrial and Epigenomic Medicine (1)
  • Center for the Investigation of Factor FVIII Immunogenicity (1)
  • Clinical Futures (1)
  • Clinical In Vivo Gene Therapy (1)
  • Division of Allergy and Immunology (1)
  • Division of Cardiology (1)
  • Division of Human Genetics (1)
  • Division of Neonatology (1)
  • Division of Oncology (1)
  • Division of Protective Immunity (1)
  • Division of Pulmonary and Sleep Medicine (1)
  • George Laboratory (1)
  • Margaritis Laboratory (1)
  • Novel Therapeutics for Bleeding Disorders (1)
  • Office of Academic Training and Outreach Programs (1)
  • PolicyLab (1)
  • Samelson-Jones Laboratory (1)
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