Dr. Rubenstein's research focuses on basic and translational studies of novel means to improve outcomes in cystic fibrosis. He initially focused on correcting the dysfunction of mutant cystic fibrosis transmembrane conductance regulator (CFTR) proteins, which led him to study how molecular chaperones regulate the biogenesis and trafficking of CFTR and other proteins that are relevant to cystic fibrosis.
Dr. Kelly is an attending physician in the Division of Endocrinology and Diabetes at Children's Hospital of Philadelphia and a professor of pediatrics at the University of Pennsylvania. Her research focuses on cystic fibrosis, bone and body composition, and endocrine co-morbidities in Down syndrome.
Christoph Seiler, PhD, received a Foerderer Fund for Excellence award at The Children’s Hospital of Philadelphia in 2015 to study this mechanism. German-born Dr. Seiler pointed out that “Foerderer,” in German, means supporter or sponsor. Its name is therefore apt, because the internal award program spurs research projects that need a bit of support to generate pilot data that can later help those projects stand out in the competitive awarding of external funds.
Focusing on the underpinnings of progressive insulin secretion defects and worsening glucose tolerance in children and adults with cystic fibrosis, and examining the links between hyperglycemia and insulin deficiency and cystic fibrosis-related outcomes.
The purpose of this research study is to examine and understand the various mechanisms that contribute to Cystic Fibrosis Related Diabetes and gain a better understanding of potential means to treat Cystic Fibrosis Related Diabetes.
The purpose of this research study is to test how people with cystic fibrosis process sugar and learn more about their risk of developing cystic fibrosis-related diabetes.
The Children’s Hospital of Philadelphia is seeking healthy adolescents and young adults ages 16-22 years old, to participate in the Muscle Accrual in Cystic Fibrosis Research Study.
