Dr. Goldberg's research focuses on children with single ventricle congenital heart disease. Much of his work centers on the consequences of the abnormal single ventricle physiology and the impact on other organ systems throughout the body. He is also interested in medical interventions designed to improve the efficiency of the post-Fontan circulation by lowering pulmonary vascular resistance.
The cure rate for children with neuroblastoma is unacceptable, making it imperative that new therapies are developed. Dr. Bosse's laboratory is focused on discovering and developing new neuroblastoma cell surface immunotherapeutic targets. Along with his colleagues, Dr. Bosse's aim is to capitalize on the robust differential expression of these molecules with immune-based therapies and also define their mechanisms of overexpression and roles in tumorigenesis.
Dr. Berg is a resuscitation scientist with extensive clinical and preclinical translational laboratory experience in the areas of cardiac arrest, VF, defibrillation, and personalized physiologic-directed CPR. He has substantial expertise in conducting multicenter observational and interventional trials.
Dr. Worthen's research program focuses on the mechanisms of acute inflammation in the lung. For more than 30 years he has worked to develop concepts, tools, and approaches to understand how neutrophils are mobilized from the bone marrow, retained within pulmonary capillaries, and migrate into the lung parenchyma and airspaces.
Dr. Margaritis uses biochemical, molecular, and complex in vivo methodology within the field of coagulation to advance the understanding of molecular mechanisms involved in pro- and anti-coagulant reactions, and translate research for the treatment of coagulation defects.
Dr. Tong investigates cytokine receptor signaling in normal and neoplastic hematopoietic development. She uses integrated approaches encompassing biochemistry, molecular biology, mouse models, and primary human samples to understand signaling events emanating from cytokine receptors that regulate the development of hematopoietic stem/progenitor cells.
Dr. Ichord participates in multiple research projects within Children’s Hospital of Philadelphia and in collaboration with other stroke investigators. Dr. Ichord is especially interested in better understanding the effect of stroke on complex brain function, such as thinking and learning, and developing new strategies to promote recovery and rehabilitation.