Dr. Krantz's lab identifies and characterizes the molecular etiology of syndromic and non-syndromic developmental disorders. He has identified genes for several genetic conditions (Cornelia de Lange Syndrome, CHOPS syndrome, Alagille syndrome, hearing loss) implicating critical molecular pathways in human disorders for the first time. He has been at the forefront of studying the integration of genomics into clinical settings.
Revolutionizing our understanding of the genetic causes and mechanisms of hyperinsulinism, developing diagnostic tools for a precision-medicine approach to treatment, and discovering new treatment options.
The Center for Applied Genomics (CAG) develops new and better ways to diagnose and treat children with genetic disorders, including attention-deficit/hyperactivity disorder, asthma, diabetes, inflammatory bowel disease (IBD), obesity, and numerous rare diseases. With a goal of generating new diagnostic tests and therapies, CAG is among the world's largest genetics research programs and the only pediatric center with state-of-the-art high-throughput genomics technology.
At the annual Ruth M. Colket Nursing Research and Evidence Based Practice Grand Rounds held at CHOP May 3, during the national celebration of Nurses Week 2016, nurses presented scholarly accomplishments that resulted from simply asking, “What if …?”
The year is off to a great start, with plenty of research news to report. This biweekly installment of In the News describes a new study in the emerging field of lymphatics, shares an editorial on advancements in neonatology, and highlights research to keep teen drivers safe.
Super Bowl Sunday is right around the corner, and our biweekly installment of In the News is the perfect playing field for us to showcase the wide range of research projects that Children's Hospital of Philadelphia experts tackle. Huddle up!