September marks National Childhood Cancer Awareness Month, and this year at Children's Hospital of Philadelphia, we kick-started the commemorative period on the heels of exciting news about breakthroughs in pediatric cancer immunotherapy research.
"Bold" is perhaps the best word to describe this week's roundup of Research Institute news, as Children's Hospital of Philadelphia nurses and investigators alike made headlines for their experimental work in pediatric CAR T-cell therapy: a cancer-fighting immunotherapy treatment that aims to re-engineer a patient's own T cells to detect and destroy tumor cells.
The Computational Epigenetics Lab develops novel algorithms and big data analytics to understand epigenetic cell identity and its dynamics in cell fate transition, organismal development, and human disease. The team disentangles cellular and physiological processes that impact DNA methylation and chromatin states.
The Mechanistic Molecular Immunology Lab integrates cutting-edge structural biology and biochemistry tools with functional immunoassays to understand the molecular basis of immune responses to viral infections and tumors, with an emphasis on the development of novel protein-based therapeutics.